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Literature summary extracted from

  • Komori, Y.; Nikai, T.
    Mucrolysin (2004), Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 705-706.
No PubMed abstract available

Application

EC Number Application Comment Organism
3.4.24.54 medicine mucrolysin possesses lethal and hemorrhagic activities, induces coagulation necrosis, bleeding into various organs, especially the heart and stomach Protobothrops mucrosquamatus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.54 1,10-phenanthroline inhibits lethal and hemorrhagic activities Protobothrops mucrosquamatus
3.4.24.54 Antivenin inhibits lethal and hemorrhagic activities Protobothrops mucrosquamatus
3.4.24.54 EDTA inhibits lethal and hemorrhagic activities Protobothrops mucrosquamatus
3.4.24.54 additional information not inhibited by DFP, p-chloromercuribenzoate or soybean trypsin inhibitor Protobothrops mucrosquamatus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.54 Protobothrops mucrosquamatus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.54 to homogeneity, by gel filtraton and ion-exchange column chromatography Protobothrops mucrosquamatus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.54 venom
-
 Protobothrops mucrosquamatus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.54 Ala-Leu + H2O
-
 Protobothrops mucrosquamatus ?
-
 ?
3.4.24.54 Dimethylcasein + H2O
-
 Protobothrops mucrosquamatus ?
-
 ?
3.4.24.54 Fibrinogen + H2O
-
 Protobothrops mucrosquamatus ?
-
 ?
3.4.24.54 Gly-Gly + H2O
-
 Protobothrops mucrosquamatus ?
-
 ?
3.4.24.54 Gly-Met + H2O
-
 Protobothrops mucrosquamatus ?
-
 ?
3.4.24.54 Gly-Pro + H2O
-
 Protobothrops mucrosquamatus ?
-
 ?
3.4.24.54 Gly-Tyr + H2O
-
 Protobothrops mucrosquamatus ?
-
 ?
3.4.24.54 His-Leu + H2O
-
 Protobothrops mucrosquamatus ?
-
 ?
3.4.24.54 insulin B chain + H2O hydrolyzes Aalpha chain first and then the Bbeta chain Protobothrops mucrosquamatus ?
-
 ?
3.4.24.54 Leu-Gly + H2O
-
 Protobothrops mucrosquamatus ?
-
 ?
3.4.24.54 Leu-Tyr + H2O
-
 Protobothrops mucrosquamatus ?
-
 ?
3.4.24.54 additional information does not hydrolyze casein Protobothrops mucrosquamatus ?
-
 ?
3.4.24.54 Tyr-Leu + H2O
-
 Protobothrops mucrosquamatus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.54 Mucrotoxin A
-
 Protobothrops mucrosquamatus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.54 8.5
-
-
 Protobothrops mucrosquamatus