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Literature summary extracted from

  • Tu, A.T.
    Ruberlysin (2004), Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 682-683.
No PubMed abstract available

Application

EC Number Application Comment Organism
3.4.24.48 medicine HT-2 has hemorrhagic and lethal activity Crotalus ruber ruber

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.48 EDTA
-
 Crotalus ruber ruber
3.4.24.48 additional information not inhibited by benzamidine Crotalus ruber ruber

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.48 Ca2+ 1.1 mol of calcium per mol of protein Crotalus ruber ruber
3.4.24.48 Zn2+ 1.1 mol of zinc per mol of protein Crotalus ruber ruber

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.48 25000
-
-
 Crotalus ruber ruber

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.48 Crotalus ruber ruber
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.48 by gel filtration and ion-exchange chromatography Crotalus ruber ruber

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.48 venom
-
 Crotalus ruber ruber
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.48 (Met)enkephalin + H2O cleavage at Gly3-Phe4 Crotalus ruber ruber ?
-
 ?
3.4.24.48 angiotensin + H2O cleavage at Pro7-Phe8 and His6-Pro7 Crotalus ruber ruber ?
-
 ?
3.4.24.48 casein + H2O
-
 Crotalus ruber ruber ?
-
 ?
3.4.24.48 Dimethylcasein + H2O
-
 Crotalus ruber ruber ?
-
 ?
3.4.24.48 Fibrinogen + H2O hydrolysis of Aalpha and Bbeta chains, whereas the gamma chain is resistant to hydrolysis Crotalus ruber ruber ?
-
 ?
3.4.24.48 hide powder azure + H2O
-
 Crotalus ruber ruber ?
-
 ?
3.4.24.48 luteinizing hormone releasing hormone + H2O cleavage at Gly6-Leu7 and Trp3-Ser4 Crotalus ruber ruber ?
-
 ?
3.4.24.48 oxidized insulin B chain + H2O
-
 Crotalus ruber ruber ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.48 Hemorrhagic toxin II
-
 Crotalus ruber ruber
3.4.24.48 HT-2
-
 Crotalus ruber ruber
3.4.24.48 red rattlesnake metalloendopeptidase
-
 Crotalus ruber ruber