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Literature summary extracted from
- Bothropasin (2004), Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 658-659.
No PubMed abstract available
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.24.49 | medicine | local tissue damage after snakebite, causes hemorrhage followed by myonecrosis and arterial necrosis after intramuscular injection of doses of 0.02 mg in mice, myonecrosis is still observed with lower doses down to 0.001 mg | Bothrops jararaca |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.49 | 1,10-phenanthroline | by 2 mM | Bothrops jararaca |  |
| 3.4.24.49 | DTT | by 2 mM | Bothrops jararaca | |
| 3.4.24.49 | EDTA | by 2 mM | Bothrops jararaca | |
| 3.4.24.49 | EGTA | by 2 mM | Bothrops jararaca | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.49 | 37300 | - |
denatured and reduced protein in the presence of EDTA, SDS-PAGE, sedimentation equilibrium | Bothrops jararaca |
| 3.4.24.49 | 48000 | - |
SDS-PAGE | Bothrops jararaca |
| 3.4.24.49 | 49870 | - |
sedimentation equilibrium | Bothrops jararaca |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.49 | Bothrops jararaca | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.24.49 | 7fold | Bothrops jararaca |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.49 | venom | - |
Bothrops jararaca | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.49 | casein + H2O | enzyme stabilized by CaCl2 | Bothrops jararaca | ? | - |
? | |
| 3.4.24.49 | Fibrin + H2O | - |
Bothrops jararaca | ? | - |
? | |
| 3.4.24.49 | fibrinogen | - |
Bothrops jararaca | ? | - |
? | |
| 3.4.24.49 | fibronectin | - |
Bothrops jararaca | ? | - |
? | |
| 3.4.24.49 | gelatin | - |
Bothrops jararaca | ? | - |
? | |
| 3.4.24.49 | type I collagen | - |
Bothrops jararaca | ? | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.49 | 8.8 | - |
- |
Bothrops jararaca |
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Release 2023.1 (January 2023)
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