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Literature summary extracted from

  • Park, P.W.; Mecham, R.P.
    Lysostaphin (2004), Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. ) Academic Press, 1, 1004-1005.
No PubMed abstract available

Application

EC Number Application Comment Organism
3.4.24.75 medicine staphylococcal disease pathogenesis Staphylococcus simulans

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.75 1,10-phenanthroline
-
 Staphylococcus simulans
3.4.24.75 EDTA
-
 Staphylococcus simulans
3.4.24.75 additional information binding of elastin to lysostaphin is not affected by exogenously added zinc, suggesting that zinc interferes directly with the catalytic activity of the enzyme Staphylococcus simulans
3.4.24.75 Zn2+
-
 Staphylococcus simulans

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.75 27000
-
 mature enzyme Staphylococcus simulans
3.4.24.75 42000
-
 preproenzyme Staphylococcus simulans

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.75 Staphylococcus simulans
-
 biovar Staphylococcus simulans staphylolyticus
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.75 ammonium sulfate precipitation and ion exchange chromatography Staphylococcus simulans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.75 Peptidoglycan + H2O
-
 Staphylococcus simulans Fragments of peptidoglycan
-
 ?
3.4.24.75 soluble elastin + H2O
-
 Staphylococcus simulans ?
-
 ?

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.4.24.75 Staphylococcus simulans mature enzyme
-
 9.7