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Literature summary extracted from

  • Tang, J.
    Gastricsin (2004), Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. ), 1, 38-43.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.23.3 DNA sequence determination Xenopus laevis
3.4.23.3 location on chromosome 6 Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.23.3 crystal structure determination Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.3 pepstatin
-
Xenopus laevis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.23.3 extracellular in gastric juice Sus scrofa
-
-
3.4.23.3 extracellular in gastric juice Xenopus laevis
-
-
3.4.23.3 extracellular in gastric juice Macaca fuscata
-
-
3.4.23.3 extracellular in gastric juice, vaginal fluid, serum, and seminal plasma, no secretion in urine Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.3 Homo sapiens
-
-
-
3.4.23.3 Macaca fuscata
-
japanese macaque
-
3.4.23.3 Sus scrofa
-
-
-
3.4.23.3 Xenopus laevis
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.23.3 proteolytic modification the zymogen pepsinogen C is activated after secretion Homo sapiens
3.4.23.3 proteolytic modification the zymogen pepsinogen C is activated after secretion Sus scrofa
3.4.23.3 proteolytic modification the zymogen pepsinogen C is activated after secretion Xenopus laevis
3.4.23.3 proteolytic modification the zymogen pepsinogen C is activated after secretion Macaca fuscata

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.23.3 native enzyme from stomach Sus scrofa
3.4.23.3 native zymogen Xenopus laevis
3.4.23.3 native zymogen Macaca fuscata
3.4.23.3 native zymogen from stomach, prostate, breast cysts fluid, and seminal plasma, native mature enzyme from gastric fluid by anion exchange chromatography Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.23.3 more restricted specificity than pepsin A, but shows preferential cleavage at Tyr-/- bonds. High activity on hemoglobin acid endopeptidase Homo sapiens
3.4.23.3 more restricted specificity than pepsin A, but shows preferential cleavage at Tyr-/- bonds. High activity on hemoglobin acid endopeptidase Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.23.3 breast cancer cell
-
Homo sapiens
-
3.4.23.3 breast cyst
-
Homo sapiens
-
3.4.23.3 gastric juice
-
Homo sapiens
-
3.4.23.3 gastric juice
-
Sus scrofa
-
3.4.23.3 gastrointestinal tract
-
Homo sapiens
-
3.4.23.3 gastrointestinal tract
-
Sus scrofa
-
3.4.23.3 gastrointestinal tract
-
Xenopus laevis
-
3.4.23.3 gastrointestinal tract
-
Macaca fuscata
-
3.4.23.3 additional information no expression in healthy breast tissue, reabsorption of zymogen from serum into kidney Homo sapiens
-
3.4.23.3 prostate gland
-
Homo sapiens
-
3.4.23.3 seminal plasma
-
Homo sapiens
-
3.4.23.3 seminal vesicle synthesis Homo sapiens
-
3.4.23.3 serum
-
Homo sapiens
-
3.4.23.3 stomach
-
Homo sapiens
-
3.4.23.3 stomach
-
Sus scrofa
-
3.4.23.3 vaginal fluid
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.3 Hemoglobin + H2O
-
Xenopus laevis ?
-
?
3.4.23.3 insulin B chain + H2O cleavage of sites Leu15-Tyr16 and Tyr16-Leu17 Macaca fuscata ?
-
?

Subunits

EC Number Subunits Comment Organism
3.4.23.3 More secondary and tertiary structure determination Homo sapiens
3.4.23.3 More structure determination Macaca fuscata

Synonyms

EC Number Synonyms Comment Organism
3.4.23.3 More the enzyme belongs to the A1 peptidase family Homo sapiens
3.4.23.3 More the enzyme belongs to the A1 peptidase family Sus scrofa
3.4.23.3 More the enzyme belongs to the A1 peptidase family Xenopus laevis
3.4.23.3 More the enzyme belongs to the A1 peptidase family Macaca fuscata
3.4.23.3 parapepsin II
-
Sus scrofa
3.4.23.3 pepsin C
-
Homo sapiens
3.4.23.3 pepsin C
-
Sus scrofa
3.4.23.3 pepsin C
-
Xenopus laevis
3.4.23.3 pepsin C
-
Macaca fuscata
3.4.23.3 pepsin II
-
Homo sapiens
3.4.23.3 seminal pepsin
-
Homo sapiens