EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.23.3 | DNA sequence determination | Xenopus laevis |
3.4.23.3 | location on chromosome 6 | Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
3.4.23.3 | crystal structure determination | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.23.3 | pepstatin | - |
Xenopus laevis |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.23.3 | extracellular | in gastric juice | Sus scrofa | - |
- |
3.4.23.3 | extracellular | in gastric juice | Xenopus laevis | - |
- |
3.4.23.3 | extracellular | in gastric juice | Macaca fuscata | - |
- |
3.4.23.3 | extracellular | in gastric juice, vaginal fluid, serum, and seminal plasma, no secretion in urine | Homo sapiens | - |
- |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.23.3 | Homo sapiens | - |
- |
- |
3.4.23.3 | Macaca fuscata | - |
japanese macaque | - |
3.4.23.3 | Sus scrofa | - |
- |
- |
3.4.23.3 | Xenopus laevis | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.4.23.3 | proteolytic modification | the zymogen pepsinogen C is activated after secretion | Homo sapiens |
3.4.23.3 | proteolytic modification | the zymogen pepsinogen C is activated after secretion | Sus scrofa |
3.4.23.3 | proteolytic modification | the zymogen pepsinogen C is activated after secretion | Xenopus laevis |
3.4.23.3 | proteolytic modification | the zymogen pepsinogen C is activated after secretion | Macaca fuscata |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.23.3 | native enzyme from stomach | Sus scrofa |
3.4.23.3 | native zymogen | Xenopus laevis |
3.4.23.3 | native zymogen | Macaca fuscata |
3.4.23.3 | native zymogen from stomach, prostate, breast cysts fluid, and seminal plasma, native mature enzyme from gastric fluid by anion exchange chromatography | Homo sapiens |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
3.4.23.3 | more restricted specificity than pepsin A, but shows preferential cleavage at Tyr-/- bonds. High activity on hemoglobin | acid endopeptidase | Homo sapiens | |
3.4.23.3 | more restricted specificity than pepsin A, but shows preferential cleavage at Tyr-/- bonds. High activity on hemoglobin | acid endopeptidase | Sus scrofa |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.23.3 | breast cancer cell | - |
Homo sapiens | - |
3.4.23.3 | breast cyst | - |
Homo sapiens | - |
3.4.23.3 | gastric juice | - |
Homo sapiens | - |
3.4.23.3 | gastric juice | - |
Sus scrofa | - |
3.4.23.3 | gastrointestinal tract | - |
Homo sapiens | - |
3.4.23.3 | gastrointestinal tract | - |
Sus scrofa | - |
3.4.23.3 | gastrointestinal tract | - |
Xenopus laevis | - |
3.4.23.3 | gastrointestinal tract | - |
Macaca fuscata | - |
3.4.23.3 | additional information | no expression in healthy breast tissue, reabsorption of zymogen from serum into kidney | Homo sapiens | - |
3.4.23.3 | prostate gland | - |
Homo sapiens | - |
3.4.23.3 | seminal plasma | - |
Homo sapiens | - |
3.4.23.3 | seminal vesicle | synthesis | Homo sapiens | - |
3.4.23.3 | serum | - |
Homo sapiens | - |
3.4.23.3 | stomach | - |
Homo sapiens | - |
3.4.23.3 | stomach | - |
Sus scrofa | - |
3.4.23.3 | vaginal fluid | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.23.3 | Hemoglobin + H2O | - |
Xenopus laevis | ? | - |
? | |
3.4.23.3 | insulin B chain + H2O | cleavage of sites Leu15-Tyr16 and Tyr16-Leu17 | Macaca fuscata | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.4.23.3 | More | secondary and tertiary structure determination | Homo sapiens |
3.4.23.3 | More | structure determination | Macaca fuscata |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.23.3 | More | the enzyme belongs to the A1 peptidase family | Homo sapiens |
3.4.23.3 | More | the enzyme belongs to the A1 peptidase family | Sus scrofa |
3.4.23.3 | More | the enzyme belongs to the A1 peptidase family | Xenopus laevis |
3.4.23.3 | More | the enzyme belongs to the A1 peptidase family | Macaca fuscata |
3.4.23.3 | parapepsin II | - |
Sus scrofa |
3.4.23.3 | pepsin C | - |
Homo sapiens |
3.4.23.3 | pepsin C | - |
Sus scrofa |
3.4.23.3 | pepsin C | - |
Xenopus laevis |
3.4.23.3 | pepsin C | - |
Macaca fuscata |
3.4.23.3 | pepsin II | - |
Homo sapiens |
3.4.23.3 | seminal pepsin | - |
Homo sapiens |