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Literature summary extracted from

  • Loh, Y.P.; Cawley, N.X.
    Yapsin A (2004), Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press, 1, 133-135.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.17 pepstatin A
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.23.17 extracellular the enzyme is secreted Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.23.17 Ca2+ stimulates, dependent on the substrate Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.23.17 68000
-
 x * 68000 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.23.17 beta-lipotropin + H2O Bos taurus
-
 ?
-
 ?
3.4.23.17 additional information Bos taurus the enzyme is highly specific for mono- and dibasic residues of prohormones, overview ?
-
 ?
3.4.23.17 pro-enkephalin + H2O Bos taurus
-
 ?
-
 ?
3.4.23.17 pro-insulin + H2O Bos taurus cleavage of a Lys-Arg-/- and Arg-Arg-/- bonds insulin chain A + insulin chain B
-
 ?
3.4.23.17 pro-neuropeptide Y + H2O Bos taurus
-
 ?
-
 ?
3.4.23.17 pro-opiomelanocortin + H2O Bos taurus hormone activation opiomelanocortin + pro-sequence of opiomelanocortin
-
 ?
3.4.23.17 pro-vasopressin + H2O Bos taurus cleavage at a monobasic residue neurophysin + glycopeptide
-
 ?
3.4.23.17 pro-vasopressin + H2O Bos taurus cleavage of a Lys-Arg-/- bond vasopressin + pro-sequence of vasopressin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.17 Bos taurus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.23.17 glycoprotein
-
 Bos taurus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.23.17 native enzyme from pituitary gland to homogeneity Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.23.17 adrenal medulla chromaffin granules Bos taurus
-
3.4.23.17 pituitary gland intermediate lobe, anterior lobe, and neural lobe secretory granules Bos taurus
-

Storage Stability

EC Number Storage Stability Organism
3.4.23.17 -20°C, purified enzyme, 2-3 days stable Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.17 beta-lipotropin + H2O
-
 Bos taurus ?
-
 ?
3.4.23.17 additional information the enzyme is highly specific for mono- and dibasic residues of prohormones, overview Bos taurus ?
-
 ?
3.4.23.17 additional information the enzyme is highly specific for mono- and dibasic residues of prohormones Bos taurus ?
-
 ?
3.4.23.17 pro-enkephalin + H2O
-
 Bos taurus ?
-
 ?
3.4.23.17 pro-insulin + H2O cleavage of a Lys-Arg-/- and Arg-Arg-/- bonds Bos taurus insulin chain A + insulin chain B
-
 ?
3.4.23.17 pro-neuropeptide Y + H2O
-
 Bos taurus ?
-
 ?
3.4.23.17 pro-opiomelanocortin + H2O
-
 Bos taurus opiomelanocortin + pro-sequence of opiomelanocortin
-
 ?
3.4.23.17 pro-opiomelanocortin + H2O hormone activation Bos taurus opiomelanocortin + pro-sequence of opiomelanocortin
-
 ?
3.4.23.17 pro-vasopressin + H2O cleavage at a monobasic residue Bos taurus neurophysin + glycopeptide
-
 ?
3.4.23.17 pro-vasopressin + H2O cleavage of a Lys-Arg-/- bond Bos taurus vasopressin + pro-sequence of vasopressin
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.23.17 ? x * 68000 Bos taurus
3.4.23.17 More immunogenic cross-reactive with anti-yapsin 1 antibodies due to high structural homology Bos taurus

Synonyms

EC Number Synonyms Comment Organism
3.4.23.17 More the enzyme belongs to the peptidase family A1 Bos taurus
3.4.23.17 PCE
-
 Bos taurus
3.4.23.17 yapsin A
-
 Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.23.17 4 5.5
-
 Bos taurus

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.4.23.17 Bos taurus
-
 4 3.5