EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.35 | 3',5'-cGMP + H2O | Bos taurus | allosteric cGMP-binding sites of PDE5 could regulate cGMP signaling by sequestering cGMP from cGMP-dependent protein kinase and perhaps from the PDE5 catalytic site as well. The cGMP sequestered by binding of cGMP to PDE5 R domain significantly dampens activation of cGMP-dependent protein kinase and hydrolysis of cGMP by PDE5 C domain | 5'-GMP | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.35 | Bos taurus | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.35 | 3',5'-cGMP + H2O | - |
Bos taurus | 5'-GMP | - |
? | |
3.1.4.35 | 3',5'-cGMP + H2O | allosteric cGMP-binding sites of PDE5 could regulate cGMP signaling by sequestering cGMP from cGMP-dependent protein kinase and perhaps from the PDE5 catalytic site as well. The cGMP sequestered by binding of cGMP to PDE5 R domain significantly dampens activation of cGMP-dependent protein kinase and hydrolysis of cGMP by PDE5 C domain | Bos taurus | 5'-GMP | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.35 | PDE5 | - |
Bos taurus |
3.1.4.35 | phosphodiesterase-5 | - |
Bos taurus |