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Literature summary extracted from

  • Drel, V.R.; Pacher, P.; Stevens, M.J.; Obrosova, I.G.
    Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells (2006), Free Radic. Biol. Med., 40, 1454-1465.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 fidarestat i.e. inhibitor F, inhibition in vivo and in vitro Homo sapiens
1.1.1.21 fidarestat i.e. inhibitor F, inhibition in vivo and in vitro Rattus norvegicus
1.1.1.21 additional information enzyme inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in high-glucose exposed mesengial cells Homo sapiens
1.1.1.21 additional information enzyme inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic kidney cortex Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.21 aldose + NADPH + H+ Homo sapiens increased enzyme activity and oxidative or nitrosative stress are involved in pathogenesis of diabetic nephropathy, overview alditol + NADP+
-
 ?
1.1.1.21 aldose + NADPH + H+ Rattus norvegicus increased enzyme activity and oxidative or nitrosative stress are involved in pathogenesis of diabetic nephropathy, overview alditol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Homo sapiens
-
-
-
1.1.1.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 kidney
-
 Homo sapiens
-
1.1.1.21 kidney
-
 Rattus norvegicus
-
1.1.1.21 mesangial cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.21 additional information
-
 enzyme activity, and sorbitol, glucose, and fructose contents in mesangial cell, overview Homo sapiens
1.1.1.21 additional information
-
 enzyme activity, and sorbitol, glucose, and fructose contents in renal cortex of control and streptozotocin-diabetic rats, determination of nitrotyrosine in control and diabetic kidney, overview Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 aldose + NADPH + H+
-
 Homo sapiens alditol + NADP+
-
 ?
1.1.1.21 aldose + NADPH + H+
-
 Rattus norvegicus alditol + NADP+
-
 ?
1.1.1.21 aldose + NADPH + H+ increased enzyme activity and oxidative or nitrosative stress are involved in pathogenesis of diabetic nephropathy, overview Homo sapiens alditol + NADP+
-
 ?
1.1.1.21 aldose + NADPH + H+ increased enzyme activity and oxidative or nitrosative stress are involved in pathogenesis of diabetic nephropathy, overview Rattus norvegicus alditol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 aldose reductase
-
 Homo sapiens
1.1.1.21 aldose reductase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.21 NADPH
-
 Homo sapiens
1.1.1.21 NADPH
-
 Rattus norvegicus