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Literature summary extracted from

  • Cho, J.H.; Ko, K.M.; Singaravelu, G.; Ahnn, J.
    Caenorhabditis elegans PMR1, a P-type calcium ATPase, is important for calcium/manganese homeostasis and oxidative stress response (2005), FEBS Lett., 579, 778-782.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.2.2.10 gene pmr1, expression pattern, overexpression of truncated pmr1 in transgenic worms Caenorhabditis elegans

Protein Variants

EC Number Protein Variants Comment Organism
7.2.2.10 additional information construction of a pmr1 knockout mutant, which shows high sensitivity to Mn2+ and EGTA, but also resistance to oxidative stress and suppression of highly reactive oxygen species sensitivity od smf3 RNA-mediated interference and daf16 worms, overview Caenorhabditis elegans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.10 Golgi apparatus
-
 Caenorhabditis elegans 5794
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.2.2.10 Ca2+
-
 Caenorhabditis elegans
7.2.2.10 Mg2+
-
 Caenorhabditis elegans
7.2.2.10 Mn2+
-
 Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.10 ATP + H2O + Ca2+/cis Caenorhabditis elegans Ca2+-dependent ATPase and ATP-dependent Ca2+ transport activities ADP + phosphate + Ca2+/trans
-
 ?
7.2.2.10 ATP + H2O + Mn2+/cis Caenorhabditis elegans Mn2+-dependent ATPase and ATP-dependent Mn2+ transport activities ADP + phosphate + Mn2+/trans
-
 ?
7.2.2.10 additional information Caenorhabditis elegans the P-type calcium ATPase is important for calcium/manganese homeostasis and oxidative stress response ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.10 Caenorhabditis elegans
-
 strains N2, daf-16(m26), and daf-2(e1370)III, gene pmr1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.10 hypodermal seam cell
-
 Caenorhabditis elegans
-
7.2.2.10 intestine
-
 Caenorhabditis elegans
-
7.2.2.10 additional information enzyme expression pattern, overview Caenorhabditis elegans
-
7.2.2.10 spermatheca
-
 Caenorhabditis elegans
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.10 ATP + H2O + Ca2+/cis Ca2+-dependent ATPase and ATP-dependent Ca2+ transport activities Caenorhabditis elegans ADP + phosphate + Ca2+/trans
-
 ?
7.2.2.10 ATP + H2O + Mn2+/cis Mn2+-dependent ATPase and ATP-dependent Mn2+ transport activities Caenorhabditis elegans ADP + phosphate + Mn2+/trans
-
 ?
7.2.2.10 additional information the P-type calcium ATPase is important for calcium/manganese homeostasis and oxidative stress response Caenorhabditis elegans ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.10 Ca2+/Mn2+ ATPase pump
-
 Caenorhabditis elegans
7.2.2.10 CePMR-1
-
 Caenorhabditis elegans
7.2.2.10 P-type calcium ATPase
-
 Caenorhabditis elegans
7.2.2.10 PMR1
-
 Caenorhabditis elegans