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Literature summary extracted from

  • Choi, Y.K.; Park, J.S.; Kong, J.S.; Morio, T.; Park, Y.S.
    D-threo-tetrahydrobiopterin is synthesized via 1-oxo-2-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum Ax2 (2005), FEBS Lett., 579, 3085-3089.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.153 additional information construction of insertion mutants, the gene disruption leads to complete loss of enzyme activity Dictyostelium discoideum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+ Dictyostelium discoideum
-
 D-sepiapterin + NADPH
-
 ?
1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+ Dictyostelium discoideum AX2
-
 D-sepiapterin + NADPH
-
 ?
1.1.1.153 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ Dictyostelium discoideum
-
 L-sepiapterin + NADPH
-
 ?
1.1.1.153 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ Dictyostelium discoideum AX2
-
 L-sepiapterin + NADPH
-
 ?
1.1.1.153 6-pyruvoyl tetrahydropterin + NADPH + H+ Dictyostelium discoideum
-
 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
 ?
1.1.1.153 additional information Dictyostelium discoideum D-threo-tetrahydrobiopterin is synthesized via 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum strain Ax2 ?
-
 ?
1.1.1.153 additional information Dictyostelium discoideum AX2 D-threo-tetrahydrobiopterin is synthesized via 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum strain Ax2 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.153 Dictyostelium discoideum
-
-
-
1.1.1.153 Dictyostelium discoideum AX2
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+
-
 Dictyostelium discoideum D-sepiapterin + NADPH
-
 ?
1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+
-
 Dictyostelium discoideum D-sepiapterin + NADPH i.e. 1'-oxo-2'-D-hydroxypropyl-dihydropterin ?
1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+
-
 Dictyostelium discoideum AX2 D-sepiapterin + NADPH
-
 ?
1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+
-
 Dictyostelium discoideum AX2 D-sepiapterin + NADPH i.e. 1'-oxo-2'-D-hydroxypropyl-dihydropterin ?
1.1.1.153 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
 Dictyostelium discoideum L-sepiapterin + NADPH
-
 ?
1.1.1.153 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
 Dictyostelium discoideum L-sepiapterin + NADPH i.e. 1'-oxo-2'-L-hydroxypropyl-dihydropterin ?
1.1.1.153 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
 Dictyostelium discoideum AX2 L-sepiapterin + NADPH
-
 ?
1.1.1.153 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
 Dictyostelium discoideum AX2 L-sepiapterin + NADPH i.e. 1'-oxo-2'-L-hydroxypropyl-dihydropterin ?
1.1.1.153 6-pyruvoyl tetrahydropterin + NADPH + H+
-
 Dictyostelium discoideum 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
 ?
1.1.1.153 6-pyruvoyl tetrahydropterin + NADPH + H+ 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin is formed by an aldose reductase-like enzyme activity, not by SR Dictyostelium discoideum 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
 ?
1.1.1.153 additional information D-threo-tetrahydrobiopterin is synthesized via 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum strain Ax2 Dictyostelium discoideum ?
-
 ?
1.1.1.153 additional information D-threo-tetrahydrobiopterin is synthesized via 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum strain Ax2 Dictyostelium discoideum AX2 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.153 SR
-
 Dictyostelium discoideum

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.153 NADP+
-
 Dictyostelium discoideum
1.1.1.153 NADPH
-
 Dictyostelium discoideum