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Literature summary extracted from

  • Basak, S.; Stewart, N.A.; Chretien, M.; Basak, A.
    Aminoethyl benzenesulfonyl fluoride and its hexapeptide (Ac-VFRSLK) conjugate are both in vitro inhibitors of subtilisin kexin isozyme-1 (2004), FEBS Lett., 573, 186-194.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.67 4-(2-aminoethyl benzene)sulfonyl fluoride i.e. AEBSF, competitive Homo sapiens
3.4.21.67 Ac-VFRSLK-4-(2-aminoethyl benzene)sulfonyl fluoride
-
Homo sapiens
3.4.21.112 4-(2-aminoethyl benzene)sulfonyl fluoride i.e. AEBSF, competitive Homo sapiens
3.4.21.112 Ac-VFRSLK-4-(2-aminoethyl benzene)sulfonyl fluoride
-
Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.67 Homo sapiens
-
secreted soluble form of isozyme-1, SK-1, recombinant protein
-
3.4.21.112 Homo sapiens
-
secreted soluble form of isozyme-1, SK-1, recombinant protein
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.67 Abz-DIYISRRLL-GTFT-Tyx-A + H2O
-
Homo sapiens Abz-DIYISRRLL + GTFT-Tyx-A
-
?
3.4.21.112 Abz-DIYISRRLL-GTFT-Tyx-A + H2O
-
Homo sapiens Abz-DIYISRRLL + GTFT-Tyx-A
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.67 kexin
-
Homo sapiens
3.4.21.67 SK-1
-
Homo sapiens
3.4.21.67 subtilisin kexin isozyme-1
-
Homo sapiens
3.4.21.112 kexin
-
Homo sapiens
3.4.21.112 SK-1
-
Homo sapiens
3.4.21.112 subtilisin kexin isozyme-1
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.67 57.7
-
Ac-VFRSLK-4-(2-aminoethyl benzene)sulfonyl fluoride substrate Abz-DIYISRRLL-GTFT-Tyx-A, 37°C, pH 7.4 Homo sapiens
3.4.21.67 231
-
4-(2-aminoethyl benzene)sulfonyl fluoride substrate Abz-DIYISRRLL-GTFT-Tyx-A, 37°C, pH 7.4 Homo sapiens
3.4.21.112 57.7
-
Ac-VFRSLK-4-(2-aminoethyl benzene)sulfonyl fluoride substrate Abz-DIYISRRLL-GTFT-Tyx-A, 37°C, pH 7.4 Homo sapiens
3.4.21.112 231
-
4-(2-aminoethyl benzene)sulfonyl fluoride substrate Abz-DIYISRRLL-GTFT-Tyx-A, 37°C, pH 7.4 Homo sapiens