EC Number | Cloned (Comment) | Organism |
---|---|---|
1.8.4.11 | gene msrA, DNA and amino acid sequence determination and analysis, expression analysis, co-expression of A-type potassium channel ShC/B and MsrA in Xenopus laevis oocytes significantly accelerating the inactivation of the channel protein, functional expression of MsrA as GST-fusion protein in Escherichia coli strain BL21 | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.4.11 | peptide-L-methionine-(S)-S-oxide + thioredoxin | Homo sapiens | substrate is oxidized A-type potassium channel ShC/B whose activity strongly depends on the oxidative state of a methionine residue in the N-terminal part of the polypeptide | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.4.11 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.8.4.11 | bone marrow | high MsrA expression level | Homo sapiens | - |
1.8.4.11 | cerebellum | high MsrA expression level | Homo sapiens | - |
1.8.4.11 | heart | ventricle, high MsrA expression level | Homo sapiens | - |
1.8.4.11 | hippocampus | high MsrA expression level | Homo sapiens | - |
1.8.4.11 | kidney | high MsrA expression level | Homo sapiens | - |
1.8.4.11 | liver | high MsrA expression level, especially in fetal liver | Homo sapiens | - |
1.8.4.11 | additional information | tissue expression analysis of MsrA, wide tissue distribution, no expression in leukemia and lymphoma cell lines | Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.8.4.11 | additional information | - |
- |
Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.4.11 | N-acetyl-L-methionine-(S)-S-oxide + DTT | stereospecific reduction | Homo sapiens | N-acetyl-L-methionine + DTT disulfide + H2O | - |
? | |
1.8.4.11 | N-acetyl-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Homo sapiens | N-acetyl-L-methionine + thioredoxin disulfide + H2O | - |
? | |
1.8.4.11 | peptide-L-methionine-(S)-S-oxide + thioredoxin | substrate is oxidized A-type potassium channel ShC/B whose activity strongly depends on the oxidative state of a methionine residue in the N-terminal part of the polypeptide | Homo sapiens | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.8.4.11 | MsrA | - |
Homo sapiens |
1.8.4.11 | peptide methionine sulfoxide reductase | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.8.4.11 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.8.4.11 | 7.4 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.8.4.11 | dithiothreitol | - |
Homo sapiens | |
1.8.4.11 | thioredoxin | - |
Homo sapiens |