Literature summary extracted from

Kobza, K.; Camporeale, G.; Rueckert, B.; Kueh, A.; Griffin, J.B.; Sarath, G.; Zempleni, J.
K4, K9 and K18 in human histone H3 are targets for biotinylation by biotinidase (2005), FEBS J., 272, 4249-4259.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.5.1.12	biocytin + H2O	Homo sapiens	biotinylation of histones by biotinidase depends on the hydrolytic cleavage of biocytin (biotinyl-epsilon-lysine), coupled to the transfer of biotinyl residue to free amino groups in histones. K4, K9 and K18 in histone H3 are good targets for biotinylation, K14 and K23 are relatively poor targets	biotin + L-lysine	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.5.1.12	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.5.1.12	biocytin + H2O	-	Homo sapiens	biotin + L-lysine	-	?
3.5.1.12	biocytin + H2O	biotinylation of histones by biotinidase depends on the hydrolytic cleavage of biocytin (biotinyl-epsilon-lysine), coupled to the transfer of biotinyl residue to free amino groups in histones. K4, K9 and K18 in histone H3 are good targets for biotinylation, K14 and K23 are relatively poor targets	Homo sapiens	biotin + L-lysine	-	?

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Release 2023.1 (January 2023)