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Literature summary extracted from

  • Srivastava, S.; Tammali, R.; Chandra, D.; Greer, D.A.; Ramana, K.V.; Bhatnagar, A.; Srivastava, S.K.
    Regulation of lens aldose reductase activity by nitric oxide (2005), Exp. Eye Res., 81, 664-672.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 nitric oxide from NO donors S-nitroso-N-acetylpenicillamine or S-nitrosoglutathione in vivo and in vitro, leads to increased S-glutathiolation of the enzyme Homo sapiens
1.1.1.21 nitric oxide from NO donors S-nitroso-N-acetylpenicillamine or S-nitrosoglutathione in vivo and in vitro, leads to increased S-glutathiolation of the enzyme Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.21 aldose + NADPH + H+ Homo sapiens first and rate-limiting step in the polyol pathway, in which reduction of glucose to sorbitol is coupled with NADPH oxidation, the enzyme activity is negatively regulated by nitric oxide in the eye lens alditol + NADP+
-
 ?
1.1.1.21 aldose + NADPH + H+ Rattus norvegicus first and rate-limiting step in the polyol pathway, in which reduction of glucose to sorbitol is coupled with NADPH oxidation, the enzyme activity is negatively regulated by nitric oxide in the eye lens, the activity in diabetic rat lens is increased due to reduced NO concentration, overview alditol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Homo sapiens
-
-
-
1.1.1.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 epithelial cell from lens Homo sapiens
-
1.1.1.21 HLE-B3 cell lens epithelial cell line Homo sapiens
-
1.1.1.21 lens cultured epithelial cells Homo sapiens
-
1.1.1.21 lens cultured, healthy and diabetic lens Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.21 1.2
-
 healthy lens Rattus norvegicus
1.1.1.21 13.6
-
 lens epithelial cell extract Homo sapiens
1.1.1.21 19.2
-
 diabetic lens Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 aldose + NADPH + H+
-
 Homo sapiens alditol + NADP+
-
 ?
1.1.1.21 aldose + NADPH + H+
-
 Rattus norvegicus alditol + NADP+
-
 ?
1.1.1.21 aldose + NADPH + H+ first and rate-limiting step in the polyol pathway, in which reduction of glucose to sorbitol is coupled with NADPH oxidation, the enzyme activity is negatively regulated by nitric oxide in the eye lens Homo sapiens alditol + NADP+
-
 ?
1.1.1.21 aldose + NADPH + H+ first and rate-limiting step in the polyol pathway, in which reduction of glucose to sorbitol is coupled with NADPH oxidation, the enzyme activity is negatively regulated by nitric oxide in the eye lens, the activity in diabetic rat lens is increased due to reduced NO concentration, overview Rattus norvegicus alditol + NADP+
-
 ?
1.1.1.21 glyceraldehyde + NADPH + H+
-
 Homo sapiens glycerol + NADP+
-
 ?
1.1.1.21 glyceraldehyde + NADPH + H+
-
 Rattus norvegicus glycerol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 aldose reductase
-
 Homo sapiens
1.1.1.21 aldose reductase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.21 37
-
 assay at Homo sapiens
1.1.1.21 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.21 7.4
-
 assay at Homo sapiens
1.1.1.21 7.4
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.21 NADPH
-
 Homo sapiens
1.1.1.21 NADPH
-
 Rattus norvegicus