Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Claus, R.; Wagner, A.; Lambert, T.
    Characterization of 11beta-hydroxysteroid dehydrogenase activity in testicular tissue of control and GnRH-immunized boars as a possible regulator of spermatogenesis (2005), Exp. Clin. Endocrinol. Diabetes, 113, 262-267.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 cortisol + NAD+ Sus scrofa isozyme 11beta-HSD2 catalyzes the reverse reaction of 11beta-HSD1 with cofactor NAD+ cortisone + NADH
-
 ir
1.1.1.B40 additional information Sus scrofa the enzyme plays a role in control of cortisol and spermatogenesis ?
-
 ?
1.1.1.146 cortisone + NADPH + H+ Sus scrofa isozyme 11beta-HSD1 catalyzes the forward reaction with cofactor NADPH cortisol + NADP+
-
 ir
1.1.1.146 additional information Sus scrofa the enzyme plays a role in control of cortisol and spermatogenesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Sus scrofa Q8MKG1
-
-
1.1.1.146 Sus scrofa Q95L61
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 testis isozyme expression analysis Sus scrofa
-
1.1.1.146 testis isozyme expression analysis Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.B40 additional information
-
 isozyme activity in testicular tissue and glucocorticoid concentration, overview; isozyme activity in testicular tissue and glucocorticoid concentration, overview Sus scrofa
1.1.1.146 additional information
-
 isozyme activity in testicular tissue and glucocorticoid concentration, overview, isozyme activity in testicular tissue and glucocorticoid concentration, overview Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 cortisol + NAD+ isozyme 11beta-HSD2 catalyzes the reverse reaction of 11beta-HSD1 with cofactor NAD+ Sus scrofa cortisone + NADH
-
 ir
1.1.1.B40 additional information the enzyme plays a role in control of cortisol and spermatogenesis Sus scrofa ?
-
 ?
1.1.1.146 cortisone + NADPH + H+ isozyme 11beta-HSD1 catalyzes the forward reaction with cofactor NADPH Sus scrofa cortisol + NADP+
-
 ir
1.1.1.146 additional information the enzyme plays a role in control of cortisol and spermatogenesis Sus scrofa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11beta-HSD 2
-
 Sus scrofa
1.1.1.146 11beta-HSD 1
-
 Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B40 NAD+
-
 Sus scrofa
1.1.1.146 NADPH
-
 Sus scrofa

Expression

EC Number Organism Comment Expression
1.1.1.B40 Sus scrofa isozyme expression analysis additional information
1.1.1.146 Sus scrofa isozyme expression analysis additional information