Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hershkovitz, L.; Beuschlein, F.; Klammer, S.; Krup, M.; Weinstein, Y.
    Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone (2006), Endocrinology, 148, 976-988.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.149 analysis the enzyme is a marker for the murine X-zone Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.149 additional information construction of 20alpha-HSD knockout animals, 20alpha-HSD is not required for the regulation of X-zone growth Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.149 additional information pregnancy induces X-zone regression and abolishes 20alphaHSD expression, which is partially restored in animals that are kept from nursing their pups Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.149 additional information
-
 additional information kinetics Mus musculus
1.1.1.149 0.0033
-
 11-deoxycorticosterone pH 7.4, 37°C Mus musculus
1.1.1.149 0.0058
-
 17alpha-hydroxyprogesterone pH 7.4, 37°C Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.149 Mg2+ activates Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.149 17alpha-hydroxyprogesterone + NAD(P)H Mus musculus progesterone catabolism 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
 r
1.1.1.149 17alpha-hydroxyprogesterone + NAD(P)H Mus musculus BALB/c progesterone catabolism 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
 r
1.1.1.149 additional information Mus musculus pregnancy induces X-zone regression and abolishes 20alphaHSD expression, which is partially restored in animals that are kept from nursing their pups, lactation inhibits enzyme expression, X-zone regulation, overview ?
-
 ?
1.1.1.149 additional information Mus musculus BALB/c pregnancy induces X-zone regression and abolishes 20alphaHSD expression, which is partially restored in animals that are kept from nursing their pups, lactation inhibits enzyme expression, X-zone regulation, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.149 Mus musculus
-
 Balb/c mice
-
1.1.1.149 Mus musculus BALB/c
-
 Balb/c mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.149 adrenal cortex
-
 Mus musculus
-
1.1.1.149 adrenal gland high expression level, expression is restricted to the X-zone, adrenal 20alpha-HSD activity in male mice peaks at 3 weeks of age and disappears thereafter, whereas 20alpha-HSD enzyme activity is maintained in adrenals from nulliparous female animals Mus musculus
-
1.1.1.149 kidney
-
 Mus musculus
-
1.1.1.149 ovary high expression level Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.149 additional information
-
 progesterone concentration in blood and tissues, overview Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.149 11-deoxycorticosterone + NAD(P)H
-
 Mus musculus 4-pregnen-20alpha,21-diol-3-one + NAD(P)+
-
 ?
1.1.1.149 11-deoxycorticosterone + NAD(P)H
-
 Mus musculus BALB/c 4-pregnen-20alpha,21-diol-3-one + NAD(P)+
-
 ?
1.1.1.149 17alpha-hydroxyprogesterone + NAD(P)H
-
 Mus musculus 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
 r
1.1.1.149 17alpha-hydroxyprogesterone + NAD(P)H progesterone catabolism Mus musculus 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
 r
1.1.1.149 17alpha-hydroxyprogesterone + NAD(P)H
-
 Mus musculus BALB/c 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
 r
1.1.1.149 17alpha-hydroxyprogesterone + NAD(P)H progesterone catabolism Mus musculus BALB/c 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
 r
1.1.1.149 additional information pregnancy induces X-zone regression and abolishes 20alphaHSD expression, which is partially restored in animals that are kept from nursing their pups, lactation inhibits enzyme expression, X-zone regulation, overview Mus musculus ?
-
 ?
1.1.1.149 additional information pregnancy induces X-zone regression and abolishes 20alphaHSD expression, which is partially restored in animals that are kept from nursing their pups, lactation inhibits enzyme expression, X-zone regulation, overview Mus musculus BALB/c ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.149 20alpha-HSD
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.149 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.149 7.4
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.149 NAD(P)+
-
 Mus musculus
1.1.1.149 NAD(P)H
-
 Mus musculus