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Literature summary extracted from

  • Ozaki, Y.; Higuchi, M.; Miura, C.; Yamaguchi, S.; Tozawa, Y.; Miura, T.
    Roles of 11beta-hydroxysteroid dehydrogenase in fish spermatogenesis (2006), Endocrinology, 147, 5139-5146.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.B40 17alpha,20beta-dihydroxy-4-pregnen-3-one activates in immature testis Anguilla japonica
1.1.1.B40 additional information the enzyme is induced by cortisol Anguilla japonica

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.B40 gene 11beta-HSDsf, DNA and amino acid sequence determination and analysis, in vitro expression of the enzyme using the wheat germ cell-free protein synthesis system Anguilla japonica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 11beta-hydroxytestosterone + NAD+ Anguilla japonica
-
 11-oxotestosterone + NADH
-
 ?
1.1.1.B40 cortisol + NAD+ Anguilla japonica
-
 cortisone + NADH
-
 ?
1.1.1.B40 additional information Anguilla japonica the enzyme plays a role in spermatogenesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Anguilla japonica Q05KC1 gene 11beta-HSDsf, enzyme short form; Japanese eel, gene 11beta-HSDsf
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 testis immature Anguilla japonica
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 11beta-hydroxytestosterone + NAD+
-
 Anguilla japonica 11-oxotestosterone + NADH
-
 ?
1.1.1.B40 cortisol + NAD+
-
 Anguilla japonica cortisone + NADH
-
 ?
1.1.1.B40 additional information the enzyme plays a role in spermatogenesis Anguilla japonica ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11beta-HSD
-
 Anguilla japonica

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.B40 25
-
 assay at Anguilla japonica

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.B40 7.4
-
 assay at Anguilla japonica

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B40 NAD+
-
 Anguilla japonica