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Literature summary extracted from

  • Groyer, G.; Eychenne, B.; Girard, C.; Rajkowski, K.; Schumacher, M.; Cadepond, F.
    Expression and functional state of the corticosteroid receptors and 11 beta-hydroxysteroid dehydrogenase type 2 in Schwann cells (2006), Endocrinology, 147, 4339-4350.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.B40 additional information isozyme 11beta-HSD2 expression is highly reduced in proliferating cells Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 cortisol + NAD+ Rattus norvegicus isozyme 11beta-HSD2 is involved in inactivation of glucocorticoids, forskolin is involved in regulation of isozyme 11beta-HSD2 via intracellular cAMP cortisone + NADH
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Rattus norvegicus
-
 isozyme 11beta-HSD2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 additional information isozyme 11beta-HSD2 expression is highly reduced in proliferating cells Rattus norvegicus
-
1.1.1.B40 Schwann cell mainly isozyme 11beta-HSD2, the concentration of isozyme 11beta-HSD1 is 10-100fold lower, expression analysis, isozyme 11beta-HSD2 shows strong expression and activity in quiescent cells Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 cortisol + NAD+ isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+ Rattus norvegicus cortisone + NADH
-
 ir
1.1.1.B40 cortisol + NAD+ isozyme 11beta-HSD2 is involved in inactivation of glucocorticoids, forskolin is involved in regulation of isozyme 11beta-HSD2 via intracellular cAMP Rattus norvegicus cortisone + NADH
-
 ir

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11beta-HSD2
-
 Rattus norvegicus
1.1.1.B40 11beta-hydroxysteroid dehydrogenase type 2
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.B40 22
-
 assay at room temperature Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B40 NAD+
-
 Rattus norvegicus