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Literature summary extracted from
- Enhancement of cortisol-induced 11beta-hydroxysteroid dehydrogenase type 1 expression by interleukin 1beta in cultured human chorionic trophoblast cells (2006), Endocrinology, 147, 2490-2495.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.146 | additional information | isozyme 11beta-HSD1 is induced by cortisol, mechanism through induction of promoter activity, overview | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.146 | membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.146 | cortisone + NADPH + H+ | Homo sapiens | isozyme 11beta-HSD1 catalyzes the forward reaction with cofactor NADPH | cortisol + NADP+ | - |
ir |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.146 | Homo sapiens | - |
isozyme 11beta-HSD1 | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.146 | chorion | chorionic trophoblast cell | Homo sapiens | - |
| 1.1.1.146 | trophoblast | chorionic trophoblast cell | Homo sapiens | - |
| 1.1.1.146 | uterus | expression of isozyme 11beta-HSD1 in intrauterine tissue, overview | Homo sapiens | - |
| 1.1.1.146 | WISH cell | amnion-derived cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.146 | cortisone + NADPH + H+ | isozyme 11beta-HSD1 catalyzes the forward reaction with cofactor NADPH | Homo sapiens | cortisol + NADP+ | - |
ir | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.146 | 11beta-HSD1 | - |
Homo sapiens |
| 1.1.1.146 | 11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.146 | 37 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.146 | 7.4 | - |
assay at | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.146 | NADPH | 11beta-HSD1 | Homo sapiens | |
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Release 2023.1 (January 2023)
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