EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.27 | additional information | interferon gamma induces CatS expression | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.22.27 | the gene encoding Cat S is located on chromosome 1q21 | Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
3.4.22.27 | determination of the crystal structure of the enzyme cocrystallized with the irreversible vinyl-sulfone inhibitor APC-2848 or with a reversible dipeptide-nitrile inhibitor, crystal structure determination of the C25S mutant cathepsin S | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.22.27 | C25S | crystal structure determination | Homo sapiens |
3.4.22.27 | additional information | generation of Cat S-deficient knockout mice mutants showing accumulation of MHC class II molecules bound to the 10 kDa fragment of Ii, knockout mice phenotype, overview | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.27 | APC-2848 | irreversible vinyl-sulfone inhibitor | Homo sapiens | |
3.4.22.27 | additional information | reversible inhibition by a dipeptide-nitrile inhibitor | Homo sapiens | |
3.4.22.27 | N-morpholinurea-leucyl-homophenylalanyl-vinylsulfone-phenyl | i.e. LHVS, irreversible inhibition, the inhibitor binds covalently to the active site, in vitro and in vivo inhibition | Homo sapiens | |
3.4.22.27 | N-morpholinurea-leucyl-homophenylalanyl-vinylsulfone-phenyl | i.e. LHVS, irreversible inhibition, the inhibitor binds covalently to the active site | Mus musculus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.22.27 | 24000 | - |
1 * 24000 | Bos taurus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.27 | Albumin + H2O | Homo sapiens | degradation | ? | - |
? | |
3.4.22.27 | Collagen + H2O | Homo sapiens | degradation | ? | - |
? | |
3.4.22.27 | Elastin + H2O | Homo sapiens | degradation | ? | - |
? | |
3.4.22.27 | Hemoglobin + H2O | Homo sapiens | degradation | ? | - |
? | |
3.4.22.27 | insulin + H2O | Homo sapiens | degradation | ? | - |
? | |
3.4.22.27 | additional information | Mus musculus | cathepsin S catalyzes a key step in antigen presentation, detailed overview | ? | - |
? | |
3.4.22.27 | additional information | Rattus norvegicus | cathepsin S catalyzes a key step in antigen presentation, detailed overview | ? | - |
? | |
3.4.22.27 | additional information | Bos taurus | cathepsin S catalyzes a key step in antigen presentation, detailed overview | ? | - |
? | |
3.4.22.27 | additional information | Homo sapiens | cathepsin S catalyzes a key step in antigen presentation, detailed overview, Cat S might be involved in psoriasis induction due to an increased interferon gamma level in the epidermis, Cat S is increased in neurons of Alzheimer's disease and Down's syndrome patients, where Cat S facilitates the formation of amyloidbeta from its precursor protein, Cat S might also be involved in asthma, Sjörgren's syndrome, allergen-specific T-cell proliferation in autoimmune processes, and atherosclerosis, overview | ? | - |
? | |
3.4.22.27 | myelin basic protein + H2O | Homo sapiens | degradation | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.22.27 | Bos taurus | - |
- |
- |
3.4.22.27 | Homo sapiens | - |
- |
- |
3.4.22.27 | Mus musculus | - |
- |
- |
3.4.22.27 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.22.27 | native enzyme from lymph node | Bos taurus |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
3.4.22.27 | similar to cathepsin L, but with much less activity on Z-Phe-Arg-/-NHMec, and more activity on the Z-Val-Val-Arg-/- compound | the catalytic triad is formed by Cys25, His164, and Asn184, the substrate binding site lies between the N-terminal and the C-terminal domain, cysteine protease mechanism, overview | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.22.27 | A20 cell | B-cell line | Mus musculus | - |
3.4.22.27 | B-cell | - |
Mus musculus | - |
3.4.22.27 | B-cell | - |
Homo sapiens | - |
3.4.22.27 | B-cell | - |
Rattus norvegicus | - |
3.4.22.27 | bone marrow | - |
Homo sapiens | - |
3.4.22.27 | brain | - |
Homo sapiens | - |
3.4.22.27 | brain | grey and white matter | Rattus norvegicus | - |
3.4.22.27 | dendritic cell | - |
Homo sapiens | - |
3.4.22.27 | dendritic cell | - |
Rattus norvegicus | - |
3.4.22.27 | gastric epithelium | - |
Homo sapiens | - |
3.4.22.27 | HaCaT cell | - |
Homo sapiens | - |
3.4.22.27 | heart | - |
Homo sapiens | - |
3.4.22.27 | HOM2 cell | B lymphoblastoid cell line | Homo sapiens | - |
3.4.22.27 | keratinocyte | - |
Homo sapiens | - |
3.4.22.27 | kidney | - |
Homo sapiens | - |
3.4.22.27 | leukocyte | - |
Homo sapiens | - |
3.4.22.27 | liver | - |
Homo sapiens | - |
3.4.22.27 | lung | - |
Homo sapiens | - |
3.4.22.27 | lymph node | - |
Homo sapiens | - |
3.4.22.27 | lymph node | - |
Bos taurus | - |
3.4.22.27 | macrophage | - |
Homo sapiens | - |
3.4.22.27 | macrophage | - |
Rattus norvegicus | - |
3.4.22.27 | microglia | - |
Rattus norvegicus | - |
3.4.22.27 | monocyte | - |
Homo sapiens | - |
3.4.22.27 | monocyte | - |
Rattus norvegicus | - |
3.4.22.27 | additional information | no expression in skeletal muscle | Homo sapiens | - |
3.4.22.27 | neuron | - |
Homo sapiens | - |
3.4.22.27 | neuron | - |
Rattus norvegicus | - |
3.4.22.27 | placenta | - |
Homo sapiens | - |
3.4.22.27 | retina | epithelium piment cells | Homo sapiens | - |
3.4.22.27 | spleen | - |
Homo sapiens | - |
3.4.22.27 | splenocyte | - |
Mus musculus | - |
3.4.22.27 | T-lymphocyte | - |
Homo sapiens | - |
3.4.22.27 | uterine endometrium | - |
Homo sapiens | - |
3.4.22.27 | vermiform appendix | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.27 | Albumin + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.22.27 | Albumin + H2O | degradation | Homo sapiens | ? | - |
? | |
3.4.22.27 | Collagen + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.22.27 | Collagen + H2O | degradation | Homo sapiens | ? | - |
? | |
3.4.22.27 | Elastin + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.22.27 | Elastin + H2O | degradation | Homo sapiens | ? | - |
? | |
3.4.22.27 | Hemoglobin + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.22.27 | Hemoglobin + H2O | degradation | Homo sapiens | ? | - |
? | |
3.4.22.27 | insulin + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.22.27 | insulin + H2O | degradation | Homo sapiens | ? | - |
? | |
3.4.22.27 | leupeptin-induced peptide LIP10 + H2O | - |
Mus musculus | ? | - |
? | |
3.4.22.27 | additional information | cathepsin S catalyzes a key step in antigen presentation, detailed overview | Mus musculus | ? | - |
? | |
3.4.22.27 | additional information | cathepsin S catalyzes a key step in antigen presentation, detailed overview | Rattus norvegicus | ? | - |
? | |
3.4.22.27 | additional information | cathepsin S catalyzes a key step in antigen presentation, detailed overview | Bos taurus | ? | - |
? | |
3.4.22.27 | additional information | cathepsin S catalyzes a key step in antigen presentation, detailed overview, Cat S might be involved in psoriasis induction due to an increased interferon gamma level in the epidermis, Cat S is increased in neurons of Alzheimer's disease and Down's syndrome patients, where Cat S facilitates the formation of amyloidbeta from its precursor protein, Cat S might also be involved in asthma, Sjörgren's syndrome, allergen-specific T-cell proliferation in autoimmune processes, and atherosclerosis, overview | Homo sapiens | ? | - |
? | |
3.4.22.27 | additional information | Cat S forms an alpha-beta-CLIP complex, unlike CatB or CatD, from an alpha-beta-Ii molecule in vitro | Mus musculus | ? | - |
? | |
3.4.22.27 | additional information | Cat S forms an alpha-beta-CLIP complex, unlike CatB or CatD, from an alpha-beta-Ii molecule in vitro | Homo sapiens | ? | - |
? | |
3.4.22.27 | myelin basic protein + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.22.27 | myelin basic protein + H2O | degradation | Homo sapiens | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.4.22.27 | monomer | 1 * 24000 | Bos taurus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.22.27 | Cat S | - |
Mus musculus |
3.4.22.27 | Cat S | - |
Homo sapiens |
3.4.22.27 | Cat S | - |
Rattus norvegicus |
3.4.22.27 | Cat S | - |
Bos taurus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.22.27 | 6.5 | - |
- |
Homo sapiens |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
3.4.22.27 | 4.5 | 7.8 | active range | Homo sapiens |