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Literature summary extracted from

  • Chuang, J.Z.; Yeh, T.Y.; Bollati, F.; Conde, C.; Canavosio, F.; Caceres, A.; Sung, C.H.
    The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth (2005), Dev. Cell, 9, 75-86.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.6.1.2 axon Tctex-1 is enriched in growing axons of cultured hippocampal neurons. The cytoplasmic dynein light chain Tctex-1 plays a key role in multiple steps of hippocampal neuron development, including initial neurite sprouting, axon specification, and later dendritic elaboration. The neuritogenic effects elicited by Tctex-1 are independent from its cargo adaptor role for dynein motor transport. The selective high level of Tctex-1 at the growth cone of growing axons drives fast neurite extension by modulating actin dynamics and also Rac1 activity Rattus norvegicus 30424
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5.6.1.2 cytoplasm
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 Rattus norvegicus 5737
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Organism

EC Number Organism UniProt Comment Textmining
5.6.1.2 Rattus norvegicus
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.1.2 neuron hippocampal neuron. Tctex-1 is enriched in growing axons of cultured hippocampal neurons. The cytoplasmic dynein light chain Tctex-1 plays a key role in multiple steps of hippocampal neuron development, including initial neurite sprouting, axon specification, and later dendritic elaboration. The neuritogenic effects elicited by Tctex-1 are independent from its cargo adaptor role for dynein motor transport. The selective high level of Tctex-1 at the growth cone of growing axons drives fast neurite extension by modulating actin dynamics and also Rac1 activity Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.2 ATP + H2O + a dynein associated with a microtubule at position n
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 Rattus norvegicus ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
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 ?
5.6.1.2 additional information the cytoplasmic dynein light chain Tctex-1 plays a key role in multiple steps of hippocampal neuron development, including initial neurite sprouting, axon specification, and later dendritic elaboration. The neuritogenic effects elicited by Tctex-1 are independent from its cargo adaptor role for dynein motor transport. the selective high level of Tctex-1 at the growth cone of growing axons drives fast neurite extension by modulating actin dynamics and also Rac1 activity: Tctex-1 may act as a regulatory link between the microtubule and microfilament cytoskeleton Rattus norvegicus ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.1.2 dynein light chain Tctex-1
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 Rattus norvegicus
5.6.1.2 Tctex-1 dynein light chain Rattus norvegicus