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Literature summary extracted from

  • Liu, G.; Nakayama, K.; Sagara, Y.; Awata, S.; Yamashita, K.; Manabe, M.; Kodama, H.
    Characterization of prolidase activity in erythrocytes from a patient with prolidase deficiency: comparison with prolidase I and II purified from normal human erythrocytes (2005), Clin. Biochem., 38, 625-631.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.13.9 D-alanine activation of isoforms prolidase I and prolidase II Homo sapiens
3.4.13.9 D-isoleucine activation of isoforms prolidase I and prolidase II Homo sapiens
3.4.13.9 D-leucine activation of isoforms prolidase I and prolidase II Homo sapiens
3.4.13.9 D-serine activation of isoforms prolidase I and prolidase II Homo sapiens
3.4.13.9 D-valine activation of isoforms prolidase I and prolidase II Homo sapiens
3.4.13.9 glycine activation of isoforms prolidase I and prolidase II Homo sapiens
3.4.13.9 L-alanine activation of isoforms prolidase I and prolidase II Homo sapiens
3.4.13.9 L-isoleucine inhibitory to enzyme isoform prolidase I, activating isoform prolidase II Homo sapiens
3.4.13.9 L-leucine inhibitory to enzyme isoform prolidase I, activating isoform prolidase II Homo sapiens
3.4.13.9 L-serine activation of isoforms prolidase I and prolidase II Homo sapiens
3.4.13.9 L-valine inhibitory to enzyme isoform prolidase I, activating isoform prolidase II Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.13.9 L-isoleucine inhibitory to enzyme isoform prolidase I, activating isoform prolidase II Homo sapiens
3.4.13.9 L-leucine inhibitory to enzyme isoform prolidase I, activating isoform prolidase II Homo sapiens
3.4.13.9 L-valine inhibitory to enzyme isoform prolidase I, activating isoform prolidase II Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.13.9 1.64
-
 Gly-L-Pro pH 7.8, 37°C, presence of 20 mM glycine, prolidase I Homo sapiens
3.4.13.9 2.3
-
 Gly-L-Pro pH 7.8, 37°C, presence of 20 mM D-valine, prolidase I Homo sapiens
3.4.13.9 2.59
-
 Gly-L-Pro pH 7.8, 37°C, prolidase I Homo sapiens
3.4.13.9 2.63
-
 Gly-L-Pro pH 7.8, 37°C, presence of 20 mM L-valine, prolidase I Homo sapiens
3.4.13.9 4.11
-
 L-Met-L-Pro pH 7.8, 37°C, presence of 20 mM glycine, prolidase I Homo sapiens
3.4.13.9 4.43
-
 L-Met-L-Pro pH 7.8, 37°C, presence of 20 mM glycine, enzyme from patient with enzyme deficiency Homo sapiens
3.4.13.9 4.65
-
 L-Met-L-Pro pH 7.8, 37°C, presence of 20 mM D-valine, prolidase I Homo sapiens
3.4.13.9 5.39
-
 L-Met-L-Pro pH 7.8, 37°C, presence of 20 mM glycine, prolidase II Homo sapiens
3.4.13.9 5.48
-
 L-Met-L-Pro pH 7.8, 37°C, presence of 20 mM L-valine, enzyme from patient with enzyme deficiency Homo sapiens
3.4.13.9 5.65
-
 L-Met-L-Pro pH 7.8, 37°C, presence of 20 mM L-valine, prolidase II Homo sapiens
3.4.13.9 6.16
-
 L-Met-L-Pro pH 7.8, 37°C, presence of 20 mM D-valine, enzyme from patient with enzyme deficiency Homo sapiens
3.4.13.9 6.33
-
 L-Met-L-Pro pH 7.8, 37°C, presence of 20 mM D-valine, prolidase II Homo sapiens
3.4.13.9 8.83
-
 L-Met-L-Pro pH 7.8, 37°C, presence of 20 mM L-valine, prolidase I Homo sapiens
3.4.13.9 9.2
-
 L-Met-L-Pro pH 7.8, 37°C, prolidase I Homo sapiens
3.4.13.9 9.65
-
 L-Met-L-Pro pH 7.8, 37°C, prolidase II Homo sapiens
3.4.13.9 9.89
-
 L-Met-L-Pro pH 7.8, 37°C, enzyme from patient with enzyme deficiency Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.13.9 Homo sapiens
-
 comparison of isoforms prolidase I and prolidase II and isoform from patient with enzyme deficiency
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.13.9 erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.13.9 Gly-L-Pro + H2O
-
 Homo sapiens Gly + L-Pro
-
 ?
3.4.13.9 L-Met-L-Pro + H2O
-
 Homo sapiens L-Met + L-Pro
-
 ?