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Literature summary extracted from

  • Wolf, I.; OKelly, J.; Rubinek, T.; Tong, M.; Nguyen, A.; Lin, B.T.; Tai, H.H.; Karlan, B.Y.; Koeffler, H.P.
    15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer (2006), Cancer Res., 66, 7818-7823.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.141 additional information enzyme up-regulation by the tumor suppressor gene CAAT/enhancer binding protein alpha Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.141 additional information enzyme silencing by RNAi method Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.141 additional information enzyme down-regulation by estrogen Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Homo sapiens catabolism of (15S)-PGE2 (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 additional information Homo sapiens the enzyme is a tumor suppressor of human breast cancer, expression of the enzyme and the estrogen receptor is correlated, silencing of the enzyme results in enhanced cancer cell proliferation, the enzyme expression is silenced in vivo in cancer cells due to promoter methylation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.141 breast cancer cell expression of the enzyme and the estrogen receptor is correlated Homo sapiens
-
1.1.1.141 BT-474 cell
-
 Homo sapiens
-
1.1.1.141 MCF-7 cell high enzyme expression level Homo sapiens
-
1.1.1.141 MDA-MB-231 cell low enzyme expression level Homo sapiens
-
1.1.1.141 T-47D cell
-
 Homo sapiens
-
1.1.1.141 ZR75-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ catabolism of (15S)-PGE2 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 additional information the enzyme is a tumor suppressor of human breast cancer, expression of the enzyme and the estrogen receptor is correlated, silencing of the enzyme results in enhanced cancer cell proliferation, the enzyme expression is silenced in vivo in cancer cells due to promoter methylation Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.141 15-hydroxyprostaglandin dehydrogenase
-
 Homo sapiens
1.1.1.141 15-PGDH
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.141 NAD+
-
 Homo sapiens