BRENDA - Enzyme Database

A novel role for human sulfiredoxin in the reversal of glutathionylation

Findlay, V.J.; Townsend, D.M.; Morris, T.E.; Fraser, J.P.; He, L.; Tew, K.D.; Cancer Res. 66, 6800-6806 (2006)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
1.8.98.2
expressed in HEK293 cells and Escherichia coli
Homo sapiens
Engineering
EC Number
Amino acid exchange
Commentary
Organism
1.8.98.2
C99S
mutant created to show the importance of the cytosine residue in the deglutathionylation function of the protein
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.8.98.2
Homo sapiens
Q9BYN0
-
-
Purification (Commentary)
EC Number
Commentary
Organism
1.8.98.2
Ni2+-NTA column chromatography
Homo sapiens
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.8.98.2
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH
-
668161
Homo sapiens
peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
-
-
?
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
1.8.98.2
expressed in HEK293 cells and Escherichia coli
Homo sapiens
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
1.8.98.2
C99S
mutant created to show the importance of the cytosine residue in the deglutathionylation function of the protein
Homo sapiens
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
1.8.98.2
Ni2+-NTA column chromatography
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.8.98.2
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH
-
668161
Homo sapiens
peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
-
-
?