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Literature summary extracted from

  • D'Angelo, A.; Garzia, L.; Andre, A.; Carotenuto, P.; Aglio, V.; Guardiola, O.; Arrigoni, G.; Cossu, A.; Palmieri, G.; Aravind, L.; Zollo, M.
    Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis (2004), Cancer Cell, 5, 137-149.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.17 expression by using a baculovirus expression system Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.17 D106A mutation does not influence h-prune phosphodiesterase activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.17 3-isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione IC50: 0.0402 mM Homo sapiens
3.1.4.17 dipyridamole IC50: 0.00078 mM Homo sapiens
3.1.4.17 vinpocetine IC50: 0.0223 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.17 0.0009
-
3',5'-cAMP
-
Homo sapiens
3.1.4.17 0.0023
-
3',5'-cGMP
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.17 additional information Homo sapiens h-prune activity is suppressed by dipyridamole and enhanced by the interaction with nm23-H1. Activity is involved in promoting cancer metastasis ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.17
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.17 3',5'-cAMP + H2O
-
Homo sapiens 5'-AMP
-
?
3.1.4.17 3',5'-cGMP + H2O
-
Homo sapiens 5'-GMP
-
?
3.1.4.17 additional information h-prune activity is suppressed by dipyridamole and enhanced by the interaction with nm23-H1. Activity is involved in promoting cancer metastasis Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.17 h-prune
-
Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.17 0.00078
-
IC50: 0.00078 mM Homo sapiens dipyridamole
3.1.4.17 0.0223
-
IC50: 0.0223 mM Homo sapiens vinpocetine
3.1.4.17 0.0402
-
IC50: 0.0402 mM Homo sapiens 3-isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione