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Literature summary extracted from
- Downregulation of osteoblast Phex expression by PTH (2005), Bone, 37, 589-598.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.24.B15 | the gene is localized on the X chromosome | Mus musculus |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.24.B15 | additional information | mutation of Phex leads to the dominant disorder hypophosphatemia which is associated with a renal waste of phosphate and defective bone mineralization | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.B15 | additional information | the major regulator of bone development and turnover PTH, commercial preperation from rat, decreases osteoblastic Phex expression and matrix mineralization in vitro and in vivo, overview | Mus musculus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.24.B15 | membrane | - |
Mus musculus | 16020 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.B15 | Mus musculus | - |
C57BL/6J mice | - |
| 3.4.24.B15 | Mus musculus C57/BL6J | - |
C57BL/6J mice | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.B15 | calvarium | - |
Mus musculus | - |
| 3.4.24.B15 | MC3T3-E1 cell | osteoblastic cell line | Mus musculus | - |
| 3.4.24.B15 | osteoblast | fully differentiated, from calvaria of newborn mice | Mus musculus | - |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.B15 | PHEX | - |
Mus musculus |
| 3.4.24.B15 | phosphate-regulating gene with homologies to endopeptidases on the X chromosome | - |
Mus musculus |
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