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Literature summary extracted from

  • Ujjinamatada, R.K.; Bhan, A.; Hosmane, R.S.
    Design of inhibitors against guanase: Synthesis and biochemical evaluation of analogues of azepinomycin (2006), Bioorg. Med. Chem. Lett., 16, 5551-5554.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.3 3-benzyl-6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione competitive; competitive, the presence of a benzyl group at position-3 enhances the inhibitory activity by greater than twofold as compared to that without the benzyl group Oryctolagus cuniculus
3.5.4.3 6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione competitive; competitive, the presence of a benzyl group at position-3 enhances the inhibitory activity by greater than twofold as compared to that without the benzyl group Oryctolagus cuniculus
3.5.4.3 6-hydroxy-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione i.e. azepinomycin Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.3 additional information
-
additional information kinetics Oryctolagus cuniculus
3.5.4.3 0.00966
-
guanine pH 7.4, 25°C Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.3 guanine + H2O Oryctolagus cuniculus
-
xanthine + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.3 Oryctolagus cuniculus
-
-
-
3.5.4.3 Oryctolagus cuniculus
-
commercial preparation
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.3 commercial preparation from liver Oryctolagus cuniculus
-
3.5.4.3 liver
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.3 guanine + H2O
-
Oryctolagus cuniculus xanthine + NH3
-
?
3.5.4.3 guanine + H2O reaction via tetrahedral intermediate Oryctolagus cuniculus xanthine + NH3
-
?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.3 GDA
-
Oryctolagus cuniculus
3.5.4.3 guanase
-
Oryctolagus cuniculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.4.3 25
-
assay at Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.3 7.4
-
assay at Oryctolagus cuniculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.4.3 0.0005
-
6-hydroxy-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione pH 7.4, 25°C Oryctolagus cuniculus
3.5.4.3 0.00201
-
3-benzyl-6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione pH 7.4, 25°C Oryctolagus cuniculus
3.5.4.3 0.00536
-
6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione pH 7.4, 25°C Oryctolagus cuniculus
3.5.4.3 0.02
-
3-benzyl-6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione pH 7.4, 25°C Oryctolagus cuniculus
3.5.4.3 0.054
-
6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione pH 7.4, 25°C Oryctolagus cuniculus