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Literature summary extracted from

  • Lota, R.K.; Dhanani, S.; Owen, C.P.; Ahmed, S.
    Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a series of 4-hydroxyphenyl ketones as potential inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) (2006), Bioorg. Med. Chem. Lett., 16, 4519-4522.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.64 1-(4-hydroxyphenyl)-butan-1-one IC50: 0.08951 mM Rattus norvegicus
1.1.1.64 1-(4-hydroxyphenyl)-ethanone IC50: 1.70892 mM Rattus norvegicus
1.1.1.64 1-(4-hydroxyphenyl)-heptan-1-one IC50: 0.0784 mM Rattus norvegicus
1.1.1.64 1-(4-hydroxyphenyl)-hexan-1-one IC50: 0.01802 mM Rattus norvegicus
1.1.1.64 1-(4-hydroxyphenyl)-nonan-1-one IC50: 0.00286 mM Rattus norvegicus
1.1.1.64 1-(4-hydroxyphenyl)-octan-1-one IC50: 0.00652 mM Rattus norvegicus
1.1.1.64 1-(4-hydroxyphenyl)-pentan-1-one IC50: 0.00497 mM; IC50: 0.06052 mM Rattus norvegicus
1.1.1.64 1-(4-hydroxyphenyl)-propan-1-one IC50: 0.15056 mM Rattus norvegicus
1.1.1.64 1-(4-hydroxyphenyl)-undeca-1-one IC50: 0.00755 mM Rattus norvegicus
1.1.1.64 7-hydroxyflavone IC50: 0.06698 mM Rattus norvegicus
1.1.1.64 baicalein IC50: 0.18592 mM Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.64 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.64 androstenedione + NADPH + H+ Rattus norvegicus
-
 testosterone + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.64 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.64 testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.64 androstenedione + NADPH + H+
-
 Rattus norvegicus testosterone + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.64 17beta-HSD3
-
 Rattus norvegicus
1.1.1.64 17beta-hydroxysteroid dehydrogenase type 3
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.64 NADPH
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.64 0.00286
-
 IC50: 0.00286 mM Rattus norvegicus 1-(4-hydroxyphenyl)-nonan-1-one
1.1.1.64 0.00497
-
 IC50: 0.00497 mM Rattus norvegicus 1-(4-hydroxyphenyl)-pentan-1-one
1.1.1.64 0.00652
-
 IC50: 0.00652 mM Rattus norvegicus 1-(4-hydroxyphenyl)-octan-1-one
1.1.1.64 0.00755
-
 IC50: 0.00755 mM Rattus norvegicus 1-(4-hydroxyphenyl)-undeca-1-one
1.1.1.64 0.01802
-
 IC50: 0.01802 mM Rattus norvegicus 1-(4-hydroxyphenyl)-hexan-1-one
1.1.1.64 0.06052
-
 IC50: 0.06052 mM Rattus norvegicus 1-(4-hydroxyphenyl)-pentan-1-one
1.1.1.64 0.06698
-
 IC50: 0.06698 mM Rattus norvegicus 7-hydroxyflavone
1.1.1.64 0.0784
-
 IC50: 0.0784 mM Rattus norvegicus 1-(4-hydroxyphenyl)-heptan-1-one
1.1.1.64 0.08951
-
 IC50: 0.08951 mM Rattus norvegicus 1-(4-hydroxyphenyl)-butan-1-one
1.1.1.64 0.15056
-
 IC50: 0.15056 mM Rattus norvegicus 1-(4-hydroxyphenyl)-propan-1-one
1.1.1.64 0.18592
-
 IC50: 0.18592 mM Rattus norvegicus baicalein
1.1.1.64 1.70892
-
 IC50: 1.70892 mM Rattus norvegicus 1-(4-hydroxyphenyl)-ethanone