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Literature summary extracted from

  • Amtul, Z.; Kausar, N.; Follmer, C.; Rozmahel, R.F.; Atta-Ur-Rahman, R.F.; Kazmi, S.A.; Shekhani, M.S.; Eriksen, J.L.; Khan, K.M.; Choudhary, M.I.
    Cysteine based novel noncompetitive inhibitors of urease(s)- distinctive inhibition susceptibility of microbial and plant ureases (2006), Bioorg. Med. Chem., 14, 6737-6744.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.5 (2S)-2-(dimethylamino)-3-(ethylthio)propan-1-ol noncompetitive, 50% inhibition at 0.040 mM Proteus mirabilis
3.5.1.5 (2S)-2-(dimethylamino)-3-(ethylthio)propan-1-ol noncompetitive, 50% inhibition at 0.029 mM Sporosarcina pasteurii
3.5.1.5 (2S)-2-(dimethylamino)-3-ethoxypropane-1-thiol noncompetitive, 50% inhibition at 0.100 mM Canavalia ensiformis
3.5.1.5 (2S)-2-(dimethylamino)-3-ethoxypropane-1-thiol noncompetitive, 50% inhibition at 0.031 mM Proteus mirabilis
3.5.1.5 (2S)-2-(dimethylamino)-3-ethoxypropane-1-thiol noncompetitive, 50% inhibition at 0.020 mM Sporosarcina pasteurii
3.5.1.5 (2S)-2-(dimethylamino)-3-mercaptopropan-1-ol noncompetitive, 50% inhibition at 0.022 mM Proteus mirabilis
3.5.1.5 (2S)-2-(dimethylamino)-3-mercaptopropan-1-ol noncompetitive, 50% inhibition at 0.025 mM Sporosarcina pasteurii
3.5.1.5 (2S)-2-(dimethylamino)-3-methoxypropane-1-thiol noncompetitive, 50% inhibition at 0.035 mM Proteus mirabilis
3.5.1.5 (2S)-2-(dimethylamino)-3-methoxypropane-1-thiol noncompetitive, 50% inhibition at 0.036 mM Sporosarcina pasteurii
3.5.1.5 additional information not inhibitory: S-ethyl-L-cysteine, (2S)-2-(dimethylamino)-3-(ethylthio)propan-1-ol, (2S)-2-(dimethylamino)-3-mercaptopropan-1-ol, (2S)-2-(dimethylamino)-3-methoxypropane-1-thiol Canavalia ensiformis
3.5.1.5 N-dimethyl-L-cysteine noncompetitive, 50% inhibition at 0.058 mM Canavalia ensiformis
3.5.1.5 N-dimethyl-L-cysteine noncompetitive, 50% inhibition at 0.05 mM Proteus mirabilis
3.5.1.5 N-dimethyl-L-cysteine noncompetitive, 50% inhibition at 0.01 mM Sporosarcina pasteurii
3.5.1.5 N-dimethyl-S-methyl-L-cysteine noncompetitive, 50% inhibition at 0.078 mM Canavalia ensiformis
3.5.1.5 N-dimethyl-S-methyl-L-cysteine noncompetitive, 50% inhibition at 0.05 mM Proteus mirabilis
3.5.1.5 N-dimethyl-S-methyl-L-cysteine noncompetitive, 50% inhibition at 0.110 mM Sporosarcina pasteurii
3.5.1.5 S-ethyl-L-cysteine noncompetitive, 50% inhibition at 0.035 mM Proteus mirabilis
3.5.1.5 S-ethyl-L-cysteine noncompetitive, 50% inhibition at 0.030 mM Sporosarcina pasteurii

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.5 Canavalia ensiformis
-
-
-
3.5.1.5 Proteus mirabilis
-
-
-
3.5.1.5 Sporosarcina pasteurii
-
-
-

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.1.5 0.002
-
 N-dimethyl-L-cysteine pH 8.2 Sporosarcina pasteurii
3.5.1.5 0.002
-
 (2S)-2-(dimethylamino)-3-ethoxypropane-1-thiol pH 8.2 Sporosarcina pasteurii
3.5.1.5 0.002
-
 (2S)-2-(dimethylamino)-3-mercaptopropan-1-ol pH 8.2 Sporosarcina pasteurii
3.5.1.5 0.002
-
 (2S)-2-(dimethylamino)-3-methoxypropane-1-thiol pH 8.2 Sporosarcina pasteurii
3.5.1.5 0.006
-
 N-dimethyl-S-methyl-L-cysteine pH 5.0 Sporosarcina pasteurii
3.5.1.5 0.008
-
 N-dimethyl-S-methyl-L-cysteine pH 8.2 Sporosarcina pasteurii
3.5.1.5 0.009
-
 N-dimethyl-L-cysteine pH 5.0 Sporosarcina pasteurii
3.5.1.5 0.011
-
 S-ethyl-L-cysteine pH 5.0 Sporosarcina pasteurii
3.5.1.5 0.013
-
 (2S)-2-(dimethylamino)-3-mercaptopropan-1-ol pH 5.0 Sporosarcina pasteurii
3.5.1.5 0.014
-
 S-ethyl-L-cysteine pH 8.2 Sporosarcina pasteurii
3.5.1.5 0.017
-
 (2S)-2-(dimethylamino)-3-(ethylthio)propan-1-ol pH 8.2 Sporosarcina pasteurii
3.5.1.5 0.018
-
 (2S)-2-(dimethylamino)-3-(ethylthio)propan-1-ol pH 5.0 Sporosarcina pasteurii
3.5.1.5 0.019
-
 (2S)-2-(dimethylamino)-3-methoxypropane-1-thiol pH 5.0 Sporosarcina pasteurii
3.5.1.5 0.055
-
 (2S)-2-(dimethylamino)-3-ethoxypropane-1-thiol pH 5.0 Sporosarcina pasteurii