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Literature summary extracted from

  • Todaka, T.; Ishida, T.; Kita, H.; Narimatsu, S.; Yamano, S.
    Bioactivation of morphine in human liver: isolation and identification of morphinone, a toxic metabolite (2005), Biol. Pharm. Bull., 28, 1275-1280.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.218 5alpha-dihydrotestosterone 0.1 mM, complete inhibition Homo sapiens
1.1.1.218 5beta-dihydrotestosterone 0.1 mM, complete inhibition Homo sapiens
1.1.1.218 androsterone 0.1 mM, 76% inhibition Homo sapiens
1.1.1.218 Barbital 1mM, 68% inhibition Homo sapiens
1.1.1.218 chenodeoxycholic acid 0.1 mM, 24% inhibition Homo sapiens
1.1.1.218 cholic acid 0.1 mM, 10% inhibition Homo sapiens
1.1.1.218 epiandrosterone 0.1 mM, 77% inhibition Homo sapiens
1.1.1.218 estradiol 0.1 mM, complete inhibition Homo sapiens
1.1.1.218 indomethacin 1 mM, 84% inhibition Homo sapiens
1.1.1.218 Ketamine 1mM, 60% inhibition Homo sapiens
1.1.1.218 lithocholic acid 0.1 mM, 75% inhibition Homo sapiens
1.1.1.218 naloxone 1mM, 61% inhibition Homo sapiens
1.1.1.218 pyrazole 1 mM, 20% inhibition Homo sapiens
1.1.1.218 testosterone 0.1 mM, 100% inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.218 5.5
-
 morphine
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.218 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.218 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.218 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.218 morphine + NAD(P)+
-
 Homo sapiens morphinone + NAD(P)H
-
 ir

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.218 9.8
-
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.218 NAD(P)+
-
 Homo sapiens