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Literature summary extracted from

  • Hedderich, R.; Hamann, N.; Bennati, M.
    Heterodisulfide reductase from methanogenic archaea: a new catalytic role for an iron-sulfur cluster (2005), Biol. Chem., 386, 961-970.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.98.1 additional information HDR is not inhibited by cysteine alkylating reagents at concentrations up to 2 mM Methanosarcina barkeri
1.8.98.1 additional information HDR is not inhibited by cysteine alkylating reagents at concentrations up to 2 mM Methanosarcina thermophila
1.8.98.1 additional information HDR is not inhibited by cysteine alkylating reagents at concentrations up to 2 mM Methanothermobacter marburgensis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.8.98.1 Iron coenzyme M binds to a [4Fe-4S] cluster in the active site Methanosarcina barkeri
1.8.98.1 Iron coenzyme M binds to a [4Fe-4S] cluster in the active site Methanosarcina thermophila
1.8.98.1 Iron coenzyme M binds to a [4Fe-4S] cluster in the active site Methanothermobacter marburgensis

Organism

EC Number Organism UniProt Comment Textmining
1.8.98.1 Methanosarcina barkeri
-
-
-
1.8.98.1 Methanosarcina thermophila
-
-
-
1.8.98.1 Methanothermobacter marburgensis
-
formerly Methanobacterium thermoautotrophicum strain Marburg
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.98.1
-
Methanosarcina barkeri
1.8.98.1
-
Methanosarcina thermophila
1.8.98.1
-
Methanothermobacter marburgensis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.98.1 coenzyme B + coenzyme M + methanophenazine
-
Methanosarcina barkeri N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
-
?
1.8.98.1 coenzyme B + coenzyme M + methanophenazine
-
Methanosarcina thermophila N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
-
?
1.8.98.1 coenzyme B + coenzyme M + methanophenazine
-
Methanothermobacter marburgensis N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
-
?
1.8.98.1 CoM-S-S-CoB + ?
-
Methanosarcina barkeri CoM-SH + CoB-SH + ?
-
?
1.8.98.1 CoM-S-S-CoB + ?
-
Methanosarcina thermophila CoM-SH + CoB-SH + ?
-
?
1.8.98.1 CoM-S-S-CoB + ?
-
Methanothermobacter marburgensis CoM-SH + CoB-SH + ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.8.98.1 HDR
-
Methanosarcina barkeri
1.8.98.1 HDR
-
Methanosarcina thermophila
1.8.98.1 HDR
-
Methanothermobacter marburgensis
1.8.98.1 HdrB catalytic subunit of HDR Methanothermobacter marburgensis
1.8.98.1 HdrC catalytic subunit of HDR Methanothermobacter marburgensis
1.8.98.1 HdrD catalytic subunit of HDR Methanosarcina barkeri
1.8.98.1 heterodisulfide reductase
-
Methanosarcina barkeri
1.8.98.1 heterodisulfide reductase
-
Methanosarcina thermophila
1.8.98.1 heterodisulfide reductase
-
Methanothermobacter marburgensis

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.98.1 FAD
-
Methanosarcina barkeri
1.8.98.1 FAD
-
Methanosarcina thermophila
1.8.98.1 FAD
-
Methanothermobacter marburgensis