Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Choi, Y.K.; Kong, J.S.; Park, Y.S.
    Functional role of sepiapterin reductase in the biosynthesis of tetrahydropteridines in Dictyostelium discoideum Ax2 (2006), Biochim. Biophys. Acta, 1760, 877-882.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH Dictyostelium discoideum
-
 tetrahydrodictyopterin + NADP+
-
 ?
1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH Dictyostelium discoideum AX2
-
 tetrahydrodictyopterin + NADP+
-
 ?
1.1.1.153 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH Dictyostelium discoideum
-
 L-erythro-tetrahydrobiopterin + NADP+
-
 ?
1.1.1.153 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH Dictyostelium discoideum AX2
-
 L-erythro-tetrahydrobiopterin + NADP+
-
 ?
1.1.1.153 6-pyruvoyltetrahydropterin + NADPH Dictyostelium discoideum
-
 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ no synthesis of the D-isomer ?
1.1.1.153 6-pyruvoyltetrahydropterin + NADPH Dictyostelium discoideum AX2
-
 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ no synthesis of the D-isomer ?
1.1.1.153 additional information Dictyostelium discoideum quantitative in vivo assay and product determination ?
-
 ?
1.1.1.153 additional information Dictyostelium discoideum AX2 quantitative in vivo assay and product determination ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.153 Dictyostelium discoideum
-
-
-
1.1.1.153 Dictyostelium discoideum AX2
-
-
-
4.2.3.12 Dictyostelium discoideum
-
-
-
4.2.3.12 Dictyostelium discoideum AX2
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.153 additional information SR gene expression and activity in different developmental stages Dictyostelium discoideum
-
4.2.3.12 cell culture the starting cells, which are harvested just after plating on the developmental plate exhibit high PTPS mRNA. After 4 h, the transcripts decrease dramatically and then remain at the levels thereafter, although increases slightly at the terminal stage (after 12 h) Dictyostelium discoideum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH
-
 Dictyostelium discoideum tetrahydrodictyopterin + NADP+
-
 ?
1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH preferred substrate Dictyostelium discoideum tetrahydrodictyopterin + NADP+
-
 ?
1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH
-
 Dictyostelium discoideum AX2 tetrahydrodictyopterin + NADP+
-
 ?
1.1.1.153 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH preferred substrate Dictyostelium discoideum AX2 tetrahydrodictyopterin + NADP+
-
 ?
1.1.1.153 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH
-
 Dictyostelium discoideum L-erythro-tetrahydrobiopterin + NADP+
-
 ?
1.1.1.153 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH
-
 Dictyostelium discoideum AX2 L-erythro-tetrahydrobiopterin + NADP+
-
 ?
1.1.1.153 6-pyruvoyltetrahydropterin + NADPH
-
 Dictyostelium discoideum 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ no synthesis of the D-isomer ?
1.1.1.153 6-pyruvoyltetrahydropterin + NADPH
-
 Dictyostelium discoideum AX2 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ no synthesis of the D-isomer ?
1.1.1.153 additional information quantitative in vivo assay and product determination Dictyostelium discoideum ?
-
 ?
1.1.1.153 additional information product determination Dictyostelium discoideum ?
-
 ?
1.1.1.153 additional information quantitative in vivo assay and product determination Dictyostelium discoideum AX2 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.153 SR
-
 Dictyostelium discoideum
4.2.3.12 PTPS
-
 Dictyostelium discoideum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.153 22
-
 assay at Dictyostelium discoideum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.153 6.5
-
 assay at Dictyostelium discoideum

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.153 NADPH
-
 Dictyostelium discoideum