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Literature summary extracted from

  • Lupi, A.; Rossi, A.; Vaghi, P.; Gallanti, A.; Cetta, G.; Forlino, A.
    N-benzyloxycarbonyl-L-proline: An in vitro and in vivo inhibitor of prolidase (2005), Biochim. Biophys. Acta, 1744, 157-163.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.13.9 N-Benzyloxycarbonyl-L-proline 90% inhibition after incubation of cell extracts at a 1:1 ratio of inhibitor to substrate Gly-L-Pro. Long-term incubation of fibroblasts with inhibitor causes mitochondria depolarization and increased cellular death Homo sapiens
3.4.13.9 N-Benzyloxycarbonyl-L-proline daily injection of inhibitor for 3 weeks results in significant reduction of enzyme activity in erythrocyte. Inhibitor is not degraded in vivo Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.13.9 Homo sapiens
-
-
-
3.4.13.9 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.13.9 erythrocyte
-
 Mus musculus
-
3.4.13.9 fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.13.9 Gly-L-Pro + H2O
-
 Mus musculus Gly + L-Pro
-
 ?
3.4.13.9 Gly-L-Pro + H2O
-
 Homo sapiens Gly + L-Pro
-
 ?