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Literature summary extracted from

  • Sumita, C.; Maeda, M.; Fujio, Y.; Kim, J.; Fujitsu, J.; Kasayama, S.; Yamamoto, I.; Azuma, J.
    Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage (2004), Biochim. Biophys. Acta, 1673, 115-121.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.47 additional information dose-dependent induction of enzyme expression by pioglitazone Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.47 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O Homo sapiens inactivation of platelet-activating factor, up-regulation of enzyme by pioglitazone reduces cell elongation 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.47 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.47 blood plasma
-
 Homo sapiens
-
3.1.1.47 THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.47 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O inactivation of platelet-activating factor, up-regulation of enzyme by pioglitazone reduces cell elongation Homo sapiens 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.47 PAF-AH
-
 Homo sapiens
3.1.1.47 platelet-activating factor acetylhydrolase
-
 Homo sapiens