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Literature summary extracted from

  • Moiseeva, N.A.; Binevski, P.V.; Baskin, II; Palyulin, V.A.; Kost, O.A.
    Role of two chloride-binding sites in functioning of testicular angiotensin-converting enzyme (2005), Biochemistry (Moscow), 70, 1167-1172.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.15.1 Cl- kcat increases with increasing KCl concentrations, reaches a maximum at about 300 mM KCl, and the begins to decrease. At relatively low concentrations chloride anions activate the C-domain of the enzyme, but at high concentrations chloride inhibits the enzyme activity. Presence of at least two chloride-binding sites in the C-domain of bovine enzyme: binding of chloride to one of the sites causes activation of the enzyme, whereas chloride binding to the second site results in inhibition of the enzymatic activity Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 Cl- kcat increases with increasing KCl concentrations, reaches a maximum at about 300 mM KCl, and the begins to decrease. At relatively low concentrations chloride anions activate the C-domain of the enzyme, but at high concentrations chloride inhibits the enzyme activity. Presence of at least two chloride-binding sites in the C-domain of bovine enzyme: binding of chloride to one of the sites causes activation of the enzyme, whereas chloride binding to the second site results in inhibition of the enzymatic activity Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.15.1 0.4
-
 benzyloxycarbonyl-Phe-His-Leu pH 7.5 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 testis
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 benzyloxycarbonyl-Phe-His-Leu + H2O
-
 Bos taurus benzyloxycarbonyl-Phe + His-Leu
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.15.1 21.5
-
 benzyloxycarbonyl-Phe-His-Leu pH 7.5 Bos taurus