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Literature summary extracted from

  • Ciulli, A.; Abell, C.
    Biophysical tools to monitor enzyme-ligand interactions of enzymes involved in vitamin biosynthesis (2005), Biochem. Soc. Trans., 33, 767-771.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.169 additional information ligand bindig modelling for inhibitor design Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.169 ketopantoate + NADPH Escherichia coli the enzyme is involved in pantothenate, i.e. vitamin B5, biosynthesis, which is a precursor for CoA pantoate + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.169 Escherichia coli
-
 gene panE
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.169 ketopantoate + NADPH the enzyme is involved in pantothenate, i.e. vitamin B5, biosynthesis, which is a precursor for CoA Escherichia coli pantoate + NADP+
-
 r
1.1.1.169 ketopantoate + NADPH the 4-proS hydrogen is transferred from NADPH to ketopantoate to form pantoate and NADP+, ligand binding analysis by NMR spectroscopy Escherichia coli pantoate + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.169 ketopantoate reductase
-
 Escherichia coli
1.1.1.169 KPR
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.169 NADP+ cofactor binding structure and thermodynamics Escherichia coli
1.1.1.169 NADPH cofactor binding structure and thermodynamics Escherichia coli