Literature summary extracted from

Laeremans, H.; Demaegdt, H.; De Backer, J.P.; Le, M.T.; Kersemans, V.; Michotte, Y.; Vauquelin, G.; Vanderheyden, P.M.
Metal ion modulation of cystinyl aminopeptidase (2005), Biochem. J., 390, 351-357.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.11.3	1,10-phenanthroline	competition between 1,10-phenanthroline and the substrate only in presence of EDTA. Inhibitory effect of EDTA plus 1,10-phenanthroline can be completely reversed by Zn2+. Ca2+ and Mg2+ increase the potency of Zn2+ for this process	Cricetulus griseus
3.4.11.3	2,2'-bipyridine	acetic acid-containing chelators potentiate the inhibitory effect of 2,2'-bipyridine. Efficiacy decreases in the order: diethylenetriamine-N,N,N',N'',N''-pentaacetic acid, EDTA, EGTA	Cricetulus griseus
3.4.11.3	diethylenetriamine-N,N,N',N'',N''-pentaacetic acid	weak	Cricetulus griseus
3.4.11.3	EDTA	weak	Cricetulus griseus
3.4.11.3	EGTA	weak	Cricetulus griseus

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
3.4.11.3	Ca2+	inhibitory effect of EDTA plus 1,10-phenanthroline can be completely reversed by Zn2+. Ca2+ and Mg2+ increase the potency of Zn2+ for this process	Cricetulus griseus
3.4.11.3	Mg2+	inhibitory effect of EDTA plus 1,10-phenanthroline can be completely reversed by Zn2+. Ca2+ and Mg2+ increase the potency of Zn2+ for this process	Cricetulus griseus
3.4.11.3	Zn2+	inhibitory effect of EDTA plus 1,10-phenanthroline can be completely reversed by Zn2+. Ca2+ and Mg2+ increase the potency of Zn2+ for this process	Cricetulus griseus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.11.3	Cricetulus griseus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.11.3	CHO-K1 cell	-	Cricetulus griseus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.11.3	L-leucine-p-nitroanilide + H2O	-	Cricetulus griseus	L-leucine + p-nitroaniline	-	?

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Release 2023.1 (January 2023)