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Literature summary extracted from

  • Molinaro, G.; Carmona, A.K.; Juliano, M.A.; Juliano, L.; Malitskaya, E.; Yessine, M.A.; Chagnon, M.; Lepage, Y.; Simmons, W.H.; Boileau, G.; Adam, A.
    Human recombinant membrane-bound aminopeptidase P: production of a soluble form and characterization using novel, internally quenched fluorescent substrates (2005), Biochem. J., 385, 389-397.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.9 1,10-phenanthroline 50% inhibition at 0.01 mM Homo sapiens
3.4.11.9 apstatin 50% inhibition at 0.0023 mM Homo sapiens
3.4.11.9 additional information not inhibitory: bestatin, phosphoamidon Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.11.9 0.018
-
 K(Dnp)PPGFSPK(Abz)NH2
-
 Homo sapiens
3.4.11.9 0.019
-
 K(Dnp)PPK(Abz)NH2
-
 Homo sapiens
3.4.11.9 0.02
-
 K(Dnp)PPGK(Abz)NH2
-
 Homo sapiens
3.4.11.9 0.056
-
 des-Arg9-bradykinin pH 7.4, 37°C Homo sapiens
3.4.11.9 0.075
-
 bradykinin pH 7.4, 37°C Homo sapiens
3.4.11.9 0.837
-
 L-Arg-L-Pro-L-Pro pH 7.4, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.9 membrane
-
 Homo sapiens 16020
-
3.4.11.9 soluble mutant form with translational stop codon at position 658 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.9 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.11.9 glycoprotein secreted enzyme mutant with translational stop codon at position 658, N-glycosylated Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.9 bradykinin + H2O
-
 Homo sapiens Arg + des-Arg-bradykinin
-
 ?
3.4.11.9 des-Arg9-bradykinin + H2O
-
 Homo sapiens ?
-
 ?
3.4.11.9 K(Dnp)PPGFSPK(Abz)NH2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.11.9 K(Dnp)PPGK(Abz)NH2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.11.9 K(Dnp)PPK(Abz)NH2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.11.9 L-Arg-L-Pro-L-Pro + H2O
-
 Homo sapiens L-Arg + L-Pro-L-Pro
-
 ?