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Literature summary extracted from

  • Rice, G.I.; Thomas, D.A.; Grant, P.J.; Turner, A.J.; Hooper, N.M.
    Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism (2004), Biochem. J., 383, 45-51.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.23 additional information carboxylalkyl compounds cilazaprilat, indolaprilat, perindoprilat, quinaprilat and spiraprilat, the thiol compounds rentiapril and zofenapril, and the phosphoryl compounds ceranopril and fosinoprilat fail to inhibit the hydrolysis of either angiotensin I or angiotensin II by ACE2 at concentrations that abolished activity of EC 3.4.15.1 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.17.23 0.0057
-
 angiotensin II 37°C, pH 7.4 Homo sapiens
3.4.17.23 0.0868
-
 angiotensin I 37°C, pH 7.4 Homo sapiens
3.4.24.11 0.1114
-
 angiotensin(1-9) 37°C, pH 7.4 Homo sapiens
3.4.24.11 0.179
-
 angiotensin II 37°C, pH 7.4 Homo sapiens
3.4.24.11 34.1
-
 angiotensin I 37°C, pH 7.4 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Homo sapiens
-
 recombinant
-
3.4.24.11 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 angiotensin I + H2O
-
 Homo sapiens angiotensin-(1-9) + Leu
-
 ?
3.4.17.23 angiotensin II + H2O
-
 Homo sapiens angiotensin-(1-7) + Phe
-
 ?
3.4.17.23 additional information no activity with angiotensin (1-9) and angiotensin(1-7) Homo sapiens ?
-
 ?
3.4.24.11 angiotensin I + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.11 angiotensin II + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.11 angiotensin(1-9) + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.11 additional information no activity with angiotensin (1-7) Homo sapiens ?
-
 ?
3.4.24.11 succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
-
 Homo sapiens
3.4.24.11 NEP
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.17.23 2.9
-
 angiotensin I 37°C, pH 7.4 Homo sapiens
3.4.17.23 12.8
-
 angiotensin II 37°C, pH 7.4 Homo sapiens
3.4.24.11 0.0551
-
 angiotensin I 37°C, pH 7.4 Homo sapiens
3.4.24.11 40
-
 angiotensin II 37°C, pH 7.4 Homo sapiens
3.4.24.11 41.8
-
 angiotensin(1-9) 37°C, pH 7.4 Homo sapiens