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Literature summary extracted from

  • Jiang, H.; Wang, X.F.; Fang, L.; Tang, C.; Zhu, Y.; Wang, X.
    Upregulation of aldose reductase by homocysteine in type II alveolar epithelial cells (2005), Biochem. Biophys. Res. Commun., 337, 1084-1091.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.21 additional information upregulation of the enzyme by homocysteine in type II alveolar epithelial cells, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.21 aldose + NADPH + H+ Homo sapiens upregulation of the enzyme by homocysteine in type II alveolar epithelial cells can lead to cell damage and pulmonary disease, overview alditol + NADP+
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?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Homo sapiens P15121
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-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 A-549 cell type II alveolar epithelial cell line, AR expression analysis Homo sapiens
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1.1.1.21 lung
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Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 aldose + NADPH + H+
-
Homo sapiens alditol + NADP+
-
?
1.1.1.21 aldose + NADPH + H+ upregulation of the enzyme by homocysteine in type II alveolar epithelial cells can lead to cell damage and pulmonary disease, overview Homo sapiens alditol + NADP+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 AKR1B1
-
Homo sapiens
1.1.1.21 aldose reductase
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Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.21 NADPH
-
Homo sapiens