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Literature summary extracted from

  • Brøndsted, L.; Andersen, M.T.; Parker, M.; Jorgensen, K.; Ingmer, H.
    The HtrA protease of Campylobacter jejuni is required for heat and oxygen tolerance and for optimal interaction with human epithelial cells (2005), Appl. Environ. Microbiol., 71, 3205-3212.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.107 puromycin increases level of misfolded proteins, HtrA is required for growth under conditions in which misfolded proteins accumulate Campylobacter jejuni

Application

EC Number Application Comment Organism
3.4.21.107 medicine HtrA is important both for adherence to and invasion of human INT407 epithelial cells Campylobacter jejuni

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.107 expression in Escherichia coli DH5alpha, BL20 and BL78 Campylobacter jejuni

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.107 additional information Escherichia coli HtrA mutant Escherichia coli
3.4.21.107 additional information mutant strain NCTC11168deltahtrA cat, main part of the HtrA gene replaced Campylobacter jejuni

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.107 additional information wild type and HtrA mutant are not sensitive to H2O2, cumene hydroperoxide and paraquat, moreover the wild type is not sensitive to oxygen while the mutant has a reduced oxygen tolerance Campylobacter jejuni

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.107 periplasm
-
 Campylobacter jejuni
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.107 Campylobacter jejuni
-
 strain NCTC11168
-
3.4.21.107 Campylobacter jejuni NCTC 11168
-
 strain NCTC11168
-
3.4.21.107 Escherichia coli
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Synonyms

EC Number Synonyms Comment Organism
3.4.21.107 HtrA protease
-
 Escherichia coli
3.4.21.107 HtrA protease
-
 Campylobacter jejuni

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
3.4.21.107 37 44 the HtrA mutant forms colonies with the same frequency as the wild type at 37°C and 42°C, the ability of the mutant to form colonies at 44°C was greatly reduced as compared to the wild type Campylobacter jejuni