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Literature summary extracted from

  • Barski, O.A.; Papusha, V.Z.; Ivanova, M.M.; Rudman, D.M.; Finegold, M.J.
    Developmental expression and function of aldehyde reductase in proximal tubules of the kidney (2005), Am. J. Physiol. Renal Physiol., 289, F200-F207.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 AL-1576 0.5 microM, (10 x KI), 13fold higher affinity for aldehyde reductase than for aldose reductase; 0.5 microM, (10 x KI), 13fold higher affinity for aldehyde reductase than for aldose reductase, reversible Mus musculus
1.1.1.19 AL-1567
-
 Homo sapiens
1.1.1.19 AL-1567
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.2 apical plasma membrane proximal tubules, high concentration Mus musculus 16324
-
1.1.1.2 cytosol low concentration Mus musculus 5829
-
1.1.1.2 membrane proximal tubules Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.2 glucuronate + NADPH Mus musculus
-
 ?
-
 ?
1.1.1.2 glucuronate + NADPH Mus musculus C57BL/6
-
 ?
-
 ?
1.1.1.2 glucuronate + NADPH + H+ Mus musculus
-
 ?
-
 ?
1.1.1.2 glucuronate + NADPH + H+ Mus musculus C57BL/6
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Mus musculus Q9JII6
-
-
1.1.1.2 Mus musculus Q9JII6 C57BL/6
-
1.1.1.2 Mus musculus C57BL/6 Q9JII6 C57BL/6
-
1.1.1.19 Homo sapiens
-
-
-
1.1.1.19 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 intestine
-
 Mus musculus
-
1.1.1.2 kidney fetal kidney, 10fold higher enzymatic activity observed compared with other tissues Mus musculus
-
1.1.1.2 kidney cortex represents as much as 1% of total cytosolic protein in the kidney Mus musculus
-
1.1.1.2 liver
-
 Mus musculus
-
1.1.1.2 stomach
-
 Mus musculus
-
1.1.1.19 intestine low activity Mus musculus
-
1.1.1.19 kidney high activity. Expression is limited to the proximal tubules and parietal epithelium of Bowman's capsule. the intensity of staining increases with age Mus musculus
-
1.1.1.19 kidney high activity. Expression is limited to the proximal tubules. Enzyme is present in the 9 week old fetal kidney Homo sapiens
-
1.1.1.19 liver low activity Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.2 additional information
-
 10fold higher enzymatic activity observed in kidney compared with other tissues, enzyme activity depends on the human´s age Mus musculus
1.1.1.2 additional information
-
 10fold higher enzymatic activity observed in kindney compare with other tissues, enzyme activity depends on the animal’s age, activity approaches a plateau by day 35 and does not differ between male and female mice Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 D-glucuronate + NADPH 0.1 M phosphat buffer, pH 7.0 Mus musculus ?
-
 ?
1.1.1.2 D-glucuronate + NADPH 0.1 M phosphat buffer, pH 7.0 Mus musculus C57BL/6 ?
-
 ?
1.1.1.2 D-glucuronate + NADPH + H+ 0.1 M phosphate buffer, pH 7.0 Mus musculus ?
-
 ?
1.1.1.2 D-glucuronate + NADPH + H+ 0.1 M phosphate buffer, pH 7.0 Mus musculus C57BL/6 ?
-
 ?
1.1.1.2 glucuronate + NADPH
-
 Mus musculus ?
-
 ?
1.1.1.2 glucuronate + NADPH
-
 Mus musculus C57BL/6 ?
-
 ?
1.1.1.2 glucuronate + NADPH + H+
-
 Mus musculus ?
-
 ?
1.1.1.2 glucuronate + NADPH + H+
-
 Mus musculus C57BL/6 ?
-
 ?
1.1.1.19 D-glucuronate + NADPH + H+
-
 Mus musculus L-gulonate + NADP+
-
 ?
1.1.1.19 D-glucuronate + NADPH + H+
-
 Homo sapiens L-gulonate + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.2 AKR1A1
-
 Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.2 7
-
 assay pH Mus musculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.2 7
-
 assay pH Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.2 NADPH
-
 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.2 additional information
-
 AL-1576
-
 Mus musculus