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Literature summary extracted from

  • Billecke, S.S.; Kitzmiller, L.A.; Northrup, J.J.; Whitesall, S.E.; Kimoto, M.; Hinz, A.V.; D'Alecy, L.G.
    Contribution of whole blood to the control of plasma asymmetrical dimethylarginine (2006), Am. J. Physiol. Heart Circ. Physiol., 291, H1788-1796.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.3.18 medicine endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (hydrolyzed by DDAH) is elevated in many patients and may contribute to the initiation and progression of their disease Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.3.18 2-amino-4-(NG-methyl-guanidino)butanoic acid incubation of lysed red blood cells, dose dependent inhibition of NG,NG-dimethyl-L-arginine degradation with the highest dose (1 mM) reversing the pattern to a net increase in NG,NG-dimethyl-L-arginine concentration for the 1- and 3h time points Rattus norvegicus
3.5.3.18 aprotinin inhibitor NG,NG-dimethyl-L-arginine release from freeze-thaw whole blood 34% inhibited Rattus norvegicus
3.5.3.18 leupeptin NG,NG-dimethyl-L-arginine release from freeze-thaw whole blood 55% inhibited Rattus norvegicus
3.5.3.18 additional information incubation of lysed red blood cells with EDTA or glucose failed to attenuate the degradation of NG,NG-dimethyl-L-arginine, incubation of whole blood cells with arginine methyltransferase inhibitors does not reduce NG,NG-dimethyl-L-arginine release Rattus norvegicus
3.5.3.18 PMSF NG,NG-dimethyl-L-arginine release from freeze-thaw whole blood 57% inhibited Rattus norvegicus
3.5.3.18 protease inhibitor NG,NG-dimethyl-L-arginine release from freeze-thaw whole blood 25-85% inhibited Rattus norvegicus
3.5.3.18 Zn2+ incubation of lysed red blood cells, diminished hydrolyis of NG,NG-dimethyl-L-arginine by addition of physiologically relevant concentrations (0.02 mM) Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.18 Rattus norvegicus
-
 male Sprague-Dawley rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.3.18 blood
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.18 NG,NG-dimethyl-L-arginine + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.3.18 DDAH
-
 Rattus norvegicus
3.5.3.18 dimethylarginine dimethylaminohydrolase
-
 Rattus norvegicus