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Literature summary extracted from

  • Garbrecht, M.R.; Schmidt, T.J.; Krozowski, Z.S.; Snyder, J.M.
    11beta-Hydroxysteroid dehydrogenase type 2 and the regulation of surfactant protein A by dexamethasone metabolites (2006), Am. J. Physiol. Endocrinol. Metab., 290, E653-E660.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.B40 carbenoxolone
-
 Homo sapiens
1.1.1.146 carbenoxolone
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.B40 microsome
-
 Homo sapiens
-
-
1.1.1.146 microsome
-
 Homo sapiens
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.B40 40000
-
 x * 40000, isozyme HSD2, SDS-PAGE Homo sapiens
1.1.1.146 40000
-
 1 * 40000, isozyme HSD1, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 cortisol + NAD+ Homo sapiens inactivation of the biologically active glucocorticoid cortisone + NADH
-
 r
1.1.1.B40 additional information Homo sapiens enzyme inhibition affects the glucocorticoid- and dexamethasone-mediated regulation of surfactant protein A metabolism, overview ?
-
 ?
1.1.1.146 cortisol + NADP+ Homo sapiens inactivation of the biologically active glucocorticoid cortisone + NADPH
-
 r
1.1.1.146 additional information Homo sapiens enzyme inhibition affects the glucocorticoid- and dexamethasone-mediated regulation of surfactant protein A metabolism, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Homo sapiens
-
 isozymes HSD1 and HSD2
-
1.1.1.146 Homo sapiens
-
 isozymes HSD1 and HSD2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 Caco-2 cell colon epithelial cell line, isozyme HSD2 Homo sapiens
-
1.1.1.B40 lung adult and fetal, isozymes HSD1 and HSD2 Homo sapiens
-
1.1.1.B40 NCI-H441 cell lung epithelial cell line, isozymes HSD1 and HSD2 Homo sapiens
-
1.1.1.146 lung adult and fetal, isozymes HSD1 and HSD2 Homo sapiens
-
1.1.1.146 NCI-H441 cell lung epithelial cell line, isozymes HSD1 and HSD2 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 cortisol + NAD+
-
 Homo sapiens cortisone + NADH
-
 r
1.1.1.B40 cortisol + NAD+ inactivation of the biologically active glucocorticoid Homo sapiens cortisone + NADH
-
 r
1.1.1.B40 additional information enzyme inhibition affects the glucocorticoid- and dexamethasone-mediated regulation of surfactant protein A metabolism, overview Homo sapiens ?
-
 ?
1.1.1.146 cortisol + NADP+
-
 Homo sapiens cortisone + NADPH
-
 r
1.1.1.146 cortisol + NADP+ inactivation of the biologically active glucocorticoid Homo sapiens cortisone + NADPH
-
 r
1.1.1.146 additional information enzyme inhibition affects the glucocorticoid- and dexamethasone-mediated regulation of surfactant protein A metabolism, overview Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.B40 dimer or trimer x * 40000, isozyme HSD2, SDS-PAGE Homo sapiens
1.1.1.146 monomer 1 * 40000, isozyme HSD1, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11beta-hydroxysteroid dehydrogenase type 2
-
 Homo sapiens
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens
1.1.1.146 HSD1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.B40 37
-
 assay at Homo sapiens
1.1.1.146 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.B40 7.4
-
 assay at Homo sapiens
1.1.1.146 7.4
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B40 NAD+
-
 Homo sapiens
1.1.1.B40 NADH
-
 Homo sapiens
1.1.1.146 NADP+
-
 Homo sapiens
1.1.1.146 NADPH
-
 Homo sapiens