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Literature summary extracted from

  • Cheng, X.W.; Kuzuya, M.; Nakamura, K.; Di, Q.; Liu, Z.; Sasaki, T.; Kanda, S.; Jin, H.; Shi, G.P.; Murohara, T.; Yokota, M.; Iguchi, A.
    Localization of cysteine protease, cathepsin S, to the surface of vascular smooth muscle cells by association with integrin alphanubeta3 (2006), Am. J. Pathol., 168, 685-694.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.27 additional information IFN-gamma and interleukin-1beta induce cathepsin S expression in smooth muscle plasma membranes Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.27 cystatin C specific endogenous inhibitor, potency against smooth muscle cell invasion, overview Homo sapiens
3.4.22.27 E64 potency against smooth muscle cell invasion, overview Homo sapiens
3.4.22.27 GM6001
-
 Homo sapiens
3.4.22.27 N-morpholinurea-leucine-homophenylalanine-vinylsulfone-phenyl i.e. LHVS, specific inhibitor, potency against smooth muscle cell invasion, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.27 cell surface of vascular smooth muscle cells, by association with integrin alphanybeta3, surface distribution Homo sapiens 9986
-
3.4.22.27 additional information the enzyme is highly expressed in artherosclerotic and neointimal lesions, active Cat S co-localizes with integrins Homo sapiens
-
-
3.4.22.27 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.27 Collagen type I + H2O Homo sapiens degradation in plasma membranes ?
-
 ?
3.4.22.27 Elastin + H2O Homo sapiens degradation in plasma membranes ?
-
 ?
3.4.22.27 additional information Homo sapiens Cat S is involved in degradtion of extracellular matrix and smooth muscle cell invasion, but not in adhesion and migration, overview, the enzyme shows elastolytic and collagenolytic activities on smooth muscle cell plasma membranes, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.27 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.27 aorta smooth muscle cells Homo sapiens
-
3.4.22.27 smooth muscle cell SMC, vascular, from aorta Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.27 Collagen type I + H2O degradation Homo sapiens ?
-
 ?
3.4.22.27 Collagen type I + H2O degradation in plasma membranes Homo sapiens ?
-
 ?
3.4.22.27 Elastin + H2O degradation in plasma membranes Homo sapiens ?
-
 ?
3.4.22.27 additional information Cat S is involved in degradtion of extracellular matrix and smooth muscle cell invasion, but not in adhesion and migration, overview, the enzyme shows elastolytic and collagenolytic activities on smooth muscle cell plasma membranes, overview Homo sapiens ?
-
 ?
3.4.22.27 additional information active Cat S co-localizes with integrins, e.g. integrin alphanubeta3 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.27 Cat S
-
 Homo sapiens