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Literature summary extracted from

  • Basso, A.; Ebert, C.; Gardossi, L.; Linda, P.; Phuong, T.T.; Zhu, M.; Wessjohann, L.
    Penicillin G amidase-catalysed hydrolysis of phenylacetic hydrazides on a solid phase: A new route to enzyme-cleavable linkers (2005), Adv. Synth. Catal., 347, 963-966.
No PubMed abstract available

Application

EC Number Application Comment Organism
3.5.1.11 synthesis hydrolysis of phenylacetic hydrazide compounds syntesized on PEGA1900 and PEGA+ copolymers of acrylamide and ethylene glycol by enzyme diffusing into the polymer. Use in specific cleavage of linkers Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.11 additional information no product inhibition by hydrazine Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.11 Escherichia coli
-
 commercial preparation, penicillin G amidase, Fluka
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.11 phenylacetamide + H2O
-
 Escherichia coli phenylacetate + NH3
-
 ?
3.5.1.11 phenylacetic hydrazide + H2O
-
 Escherichia coli phenylacetate + hydrazine
-
 ?