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Literature summary extracted from

  • Quistad, G.B.; Klintenberg, R.; Caboni, P.; Liang, S.N.; Casida, J.E.
    Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice (2006), Toxicol. Appl. Pharmacol., 211, 78-83.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.23 benzol IC50 is 0.012 mM Mus musculus
3.1.1.23 chlorpyrifos oxon IC50 is 34 nM Mus musculus
3.1.1.23 decyl benzodioxaphosphorin oxide IC50 is 0.80 nM Mus musculus
3.1.1.23 diazoxon IC50 is 0.014 mM Mus musculus
3.1.1.23 dichlorvos IC50 is 0.013 mM Mus musculus
3.1.1.23 diisopropyl fluorophosphate i.e. DFP, n-C8H17P(O)(OCH3)F, IC50 is 0.045 mM Mus musculus
3.1.1.23 dodecyl benzodioxaphosphorin oxide IC50 is 0.83 nM Mus musculus
3.1.1.23 dodecyl sulfonyl fluoride IC50 is 200 nM Mus musculus
3.1.1.23 ethyl octylphosphonofluoridate i.e. EOFP, n-C8H17P(O)(OC2H5)F, IC50 is 3.0 nM Mus musculus
3.1.1.23 heptyl benzodioxaphosphorin oxide IC50 is 45 nM Mus musculus
3.1.1.23 isopropyl dodecylfluorophosphate i.e. IDFP, n-C12H25P(O)(OCH3)F, IC50 is 0.76 nM Mus musculus
3.1.1.23 methyl arachidonyl fluorophosphonate i.e. MAFP, n-C20H33P(O)(OCH3)F Mus musculus
3.1.1.23 methyl octylphosphonofluoridate i.e. MOFP, n-C8H17P(O)(OCH3)F, IC50 is 3.0 nM Mus musculus
3.1.1.23 additional information analysis of structure-function relationships; analysis of structure-function relationships, organophosphorus-induced in vivo inhibition, overview Mus musculus
3.1.1.23 N-n-heptyl benzodioxaphosphorin oxide IC50 is 150 nM Mus musculus
3.1.1.23 O-n-octyl benzodioxaphosphorin oxide IC50 is 150 nM Mus musculus
3.1.1.23 octyl sulfonyl fluoride IC50 is 140 nM Mus musculus
3.1.1.23 paraoxon IC50 is 0.0023 mM Mus musculus
3.1.1.23 S-heptyl benzodioxaphosphorin oxide IC50 is 2.9 nM Mus musculus
3.1.1.23 S-nonyl benzodioxaphosphorin oxide IC50 is 0.31 nM Mus musculus
3.1.1.23 S-pentyl benzodioxaphosphorin oxide IC50 is 3.1 nM Mus musculus
3.1.1.23 stearyl benzodioxaphosphorin oxide IC50 is 51 nM Mus musculus
3.5.1.99 benzol
-
 Mus musculus
3.5.1.99 chlorpyrifos oxon
-
 Mus musculus
3.5.1.99 decyl benzodioxaphosphorin oxide
-
 Mus musculus
3.5.1.99 diazoxon
-
 Mus musculus
3.5.1.99 dichlorvos
-
 Mus musculus
3.5.1.99 diisopropyl fluorophosphate
-
 Mus musculus
3.5.1.99 dodecyl benzodioxaphosphorin oxide
-
 Mus musculus
3.5.1.99 dodecyl sulfonyl fluoride
-
 Mus musculus
3.5.1.99 ethyl octylphosphonofluoridate
-
 Mus musculus
3.5.1.99 heptyl benzodioxaphosphorin oxide
-
 Mus musculus
3.5.1.99 isopropyl dodecylfluorophosphate
-
 Mus musculus
3.5.1.99 methyl arachidonylfluoroposphate
-
 Mus musculus
3.5.1.99 methyl octylphosphonofluoridate
-
 Mus musculus
3.5.1.99 N-n-heptyl benzodioxaphosphorin oxide
-
 Mus musculus
3.5.1.99 O-n-octyl benzodioxaphosphorin oxide
-
 Mus musculus
3.5.1.99 octyl sulfonyl fluoride
-
 Mus musculus
3.5.1.99 paraoxon
-
 Mus musculus
3.5.1.99 S-heptyl benzodioxaphosphorin oxide
-
 Mus musculus
3.5.1.99 S-nonyl benzodioxaphosphorin oxide
-
 Mus musculus
3.5.1.99 S-pentyl benzodioxaphosphorin oxide
-
 Mus musculus
3.5.1.99 stearyl benzodioxaphosphorin oxide
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.23 Mus musculus
-
 male albino Swiss-Webster mice
-
3.5.1.99 Mus musculus
-
 Male albino Swiss–Webster
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.23 brain
-
 Mus musculus
-
3.5.1.99 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.23 1-arachidonoylglycerol + H2O
-
 Mus musculus arachidonic acid + glycerol
-
 ?
3.1.1.23 1-oleoylglycerol + H2O
-
 Mus musculus oleic acid + glycerol
-
 ?
3.1.1.23 2-arachidonoylglycerol + H2O
-
 Mus musculus arachidonic acid + glycerol
-
 ?
3.1.1.23 2-oleoylglycerol + H2O
-
 Mus musculus oleic acid + glycerol
-
 ?
3.1.1.23 3-oleoylglycerol + H2O
-
 Mus musculus oleic acid + glycerol
-
 ?
3.1.1.23 additional information enzyme activity with 1-, 2-, and 3- monoacylglycerols as substrates is similar Mus musculus ?
-
 ?
3.1.1.23 additional information enzyme activity with 1-, 2-, and 3-monoacylglycerols as substrates is similar Mus musculus ?
-
 ?
3.5.1.99 anandamide + H2O
-
 Mus musculus ethanolamine + arachidonic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.23 MAG lipase
-
 Mus musculus
3.1.1.23 monoacylglycerol lipase
-
 Mus musculus
3.5.1.99 FAAH
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.23 25
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.23 8.8
-
 assay at Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.23 0.00000076
-
 i.e. IDFP, n-C12H25P(O)(OCH3)F, IC50 is 0.76 nM Mus musculus isopropyl dodecylfluorophosphate
3.1.1.23 0.0000008
-
 IC50 is 0.80 nM Mus musculus decyl benzodioxaphosphorin oxide
3.1.1.23 0.00000083
-
 IC50 is 0.83 nM Mus musculus dodecyl benzodioxaphosphorin oxide
3.1.1.23 0.0000029
-
 IC50 is 2.9 nM Mus musculus S-heptyl benzodioxaphosphorin oxide
3.1.1.23 0.000003
-
 i.e. EOFP, n-C8H17P(O)(OC2H5)F, IC50 is 3.0 nM Mus musculus ethyl octylphosphonofluoridate
3.1.1.23 0.000003
-
 i.e. MOFP, n-C8H17P(O)(OCH3)F, IC50 is 3.0 nM Mus musculus methyl octylphosphonofluoridate
3.1.1.23 0.0000031
-
 IC50 is 3.1 nM Mus musculus S-pentyl benzodioxaphosphorin oxide
3.1.1.23 0.000034
-
 IC50 is 34 nM Mus musculus chlorpyrifos oxon
3.1.1.23 0.000045
-
 IC50 is 45 nM Mus musculus heptyl benzodioxaphosphorin oxide
3.1.1.23 0.000051
-
 IC50 is 51 nM Mus musculus stearyl benzodioxaphosphorin oxide
3.1.1.23 0.00014
-
 IC50 is 140 nM Mus musculus octyl sulfonyl fluoride
3.1.1.23 0.00015
-
 IC50 is 150 nM Mus musculus O-n-octyl benzodioxaphosphorin oxide
3.1.1.23 0.00015
-
 IC50 is 150 nM Mus musculus N-n-heptyl benzodioxaphosphorin oxide
3.1.1.23 0.0002
-
 IC50 is 200 nM Mus musculus dodecyl sulfonyl fluoride
3.1.1.23 0.0023
-
 IC50 is 0.0023 mM Mus musculus paraoxon
3.1.1.23 0.012
-
 IC50 is 0.012 mM Mus musculus benzol
3.1.1.23 0.013
-
 IC50 is 0.013 mM Mus musculus dichlorvos
3.1.1.23 0.014
-
 IC50 is 0.014 mM Mus musculus diazoxon
3.1.1.23 0.045
-
 i.e. DFP, n-C8H17P(O)(OCH3)F, IC50 is 0.045 mM Mus musculus diisopropyl fluorophosphate
3.1.1.23 0.31
-
 IC50 is 0.31 nM Mus musculus S-nonyl benzodioxaphosphorin oxide
3.5.1.99 0.0000001
-
-
 Mus musculus methyl arachidonylfluoroposphate
3.5.1.99 0.00000015
-
-
 Mus musculus S-nonyl benzodioxaphosphorin oxide
3.5.1.99 0.0000005
-
-
 Mus musculus dodecyl benzodioxaphosphorin oxide
3.5.1.99 0.0000006
-
-
 Mus musculus ethyl octylphosphonofluoridate
3.5.1.99 0.00000079
-
-
 Mus musculus methyl octylphosphonofluoridate
3.5.1.99 0.0000012
-
-
 Mus musculus decyl benzodioxaphosphorin oxide
3.5.1.99 0.0000017
-
-
 Mus musculus S-heptyl benzodioxaphosphorin oxide
3.5.1.99 0.000002
-
-
 Mus musculus isopropyl dodecylfluorophosphate
3.5.1.99 0.000002
-
-
 Mus musculus dodecyl sulfonyl fluoride
3.5.1.99 0.0000057
-
-
 Mus musculus S-pentyl benzodioxaphosphorin oxide
3.5.1.99 0.000019
-
-
 Mus musculus octyl sulfonyl fluoride
3.5.1.99 0.00004
-
-
 Mus musculus chlorpyrifos oxon
3.5.1.99 0.000064
-
-
 Mus musculus N-n-heptyl benzodioxaphosphorin oxide
3.5.1.99 0.000073
-
-
 Mus musculus O-n-octyl benzodioxaphosphorin oxide
3.5.1.99 0.000126
-
-
 Mus musculus heptyl benzodioxaphosphorin oxide
3.5.1.99 0.000131
-
-
 Mus musculus stearyl benzodioxaphosphorin oxide
3.5.1.99 0.00054
-
-
 Mus musculus paraoxon
3.5.1.99 0.0018
-
-
 Mus musculus dichlorvos
3.5.1.99 0.009
-
-
 Mus musculus diazoxon
3.5.1.99 0.011
-
-
 Mus musculus benzol
3.5.1.99 0.048
-
-
 Mus musculus diisopropyl fluorophosphate