BRENDA - Enzyme Database

Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases

Pyne, S.; Kong, K.C.; Darroch, P.I.; Semin. Cell Dev. Biol. 15, 491-501 (2004)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
3.1.3.4
expression of LPP1 in Drosophila melanogaster cells S2
Mus musculus
3.1.3.4
overexpression of LPPs in HEK293 cells, expression of LPP3 in Drosophila melanogaster cells S2
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.3.4
additional information
no inhibition by NEM
Drosophila melanogaster
3.1.3.4
additional information
no inhibition by NEM
Homo sapiens
3.1.3.4
additional information
no inhibition by NEM
Mus musculus
3.1.3.4
additional information
no inhibition by NEM
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.4
caveola
isozymes LPP1 and LPP3
Homo sapiens
5901
-
3.1.3.4
caveola
isozymes LPP1 and LPP3
Mus musculus
5901
-
3.1.3.4
caveola
isozymes LPP1 and LPP3
Rattus norvegicus
5901
-
3.1.3.4
endoplasmic reticulum
isozyme LPP3
Homo sapiens
5783
-
3.1.3.4
endoplasmic reticulum
isozyme LPP3
Mus musculus
5783
-
3.1.3.4
endoplasmic reticulum
isozyme LPP3
Rattus norvegicus
5783
-
3.1.3.4
membrane
integral
Drosophila melanogaster
16020
-
3.1.3.4
membrane
integral
Homo sapiens
16020
-
3.1.3.4
membrane
integral
Mus musculus
16020
-
3.1.3.4
membrane
integral
Rattus norvegicus
16020
-
3.1.3.4
additional information
the enzyme also hydrolyses extracellularly located substrates
Drosophila melanogaster
-
-
3.1.3.4
additional information
the enzyme also hydrolyses extracellularly located substrates
Homo sapiens
-
-
3.1.3.4
additional information
the enzyme also hydrolyses extracellularly located substrates
Mus musculus
-
-
3.1.3.4
additional information
the enzyme also hydrolyses extracellularly located substrates
Rattus norvegicus
-
-
3.1.3.4
plasma membrane
-
Drosophila melanogaster
5886
-
3.1.3.4
plasma membrane
-
Homo sapiens
5886
-
3.1.3.4
plasma membrane
-
Mus musculus
5886
-
3.1.3.4
plasma membrane
-
Rattus norvegicus
5886
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.3.4
additional information
no requirement for Mg2+
Drosophila melanogaster
3.1.3.4
additional information
no requirement for Mg2+
Homo sapiens
3.1.3.4
additional information
no requirement for Mg2+
Mus musculus
3.1.3.4
additional information
no requirement for Mg2+
Rattus norvegicus
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
3.1.3.4
53000
83000
-
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
additional information
Mus musculus
LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes
?
-
-
-
3.1.3.4
additional information
Homo sapiens
LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes
?
-
-
-
3.1.3.4
additional information
Rattus norvegicus
LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes
?
-
-
-
3.1.3.4
additional information
Drosophila melanogaster
Wunen and Wunen2 are involved in regulation of bioactive lipids and in survival and migration of germ cells, physiological roles of LPP isozymes
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.3.4
Drosophila melanogaster
-
-
-
3.1.3.4
Homo sapiens
-
isozymes LPP1-3, several splicing variants of LPP1
-
3.1.3.4
Mus musculus
-
isozymes LPP1-3, several splicing variants of LPP1
-
3.1.3.4
Rattus norvegicus
-
isozymes LPP1-3, several splicing variants of LPP1
-
Posttranslational Modification
EC Number
Posttranslational Modification
Commentary
Organism
3.1.3.4
glycoprotein
the glycosylation is not required for catalytic activity, no glycosylation of PRG-1
Homo sapiens
3.1.3.4
glycoprotein
the glycosylation is not required for catalytic activity, no glycosylation of PRG-1
Mus musculus
3.1.3.4
glycoprotein
the glycosylation is not required for catalytic activity, no glycosylation of PRG-1
Rattus norvegicus
3.1.3.4
phosphoprotein
reversible phosphorylation might play a role in enzyme regulation
Homo sapiens
3.1.3.4
phosphoprotein
reversible phosphorylation might play a role in enzyme regulation
Mus musculus
3.1.3.4
phosphoprotein
reversible phosphorylation might play a role in enzyme regulation
Rattus norvegicus
Purification (Commentary)
EC Number
Commentary
Organism
3.1.3.4
from liver
Rattus norvegicus
3.1.3.4
recombinant LPP1 from Drosophila melanogaster cells S2 by immunoaffinity
Mus musculus
3.1.3.4
recombinant LPP3 from Drosophila melanogaster cells S2 by immunoaffinity
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
adipocyte
-
Rattus norvegicus
-
3.1.3.4
brain
isozyme LPP2
Homo sapiens
-
3.1.3.4
embryo
expression pattern of Wun and Wun2 during embryogenesis
Drosophila melanogaster
-
3.1.3.4
epithelium
-
Rattus norvegicus
-
3.1.3.4
germ cell
-
Drosophila melanogaster
-
3.1.3.4
gonad
-
Drosophila melanogaster
-
3.1.3.4
hindgut
primordium
Drosophila melanogaster
-
3.1.3.4
intestinal epithelium
isozyme LPP3
Homo sapiens
-
3.1.3.4
intestinal epithelium
isozyme LPP3
Mus musculus
-
3.1.3.4
intestinal epithelium
isozyme LPP3
Rattus norvegicus
-
3.1.3.4
kidney
isozyme LPP2
Mus musculus
-
3.1.3.4
liver
isozyme LPP2
Mus musculus
-
3.1.3.4
liver
-
Rattus norvegicus
-
3.1.3.4
lung
isozyme LPP2
Mus musculus
-
3.1.3.4
mesoderm
-
Drosophila melanogaster
-
3.1.3.4
midgut
-
Drosophila melanogaster
-
3.1.3.4
additional information
expression pattern and translocation of Wun and Wun2 during gut development
Drosophila melanogaster
-
3.1.3.4
additional information
isozymes LPP1 and LPP3 show a wide tissue distribution
Homo sapiens
-
3.1.3.4
additional information
isozymes LPP1 and LPP3 show a wide tissue distribution
Mus musculus
-
3.1.3.4
additional information
the expression of LPP1-3 is reduced upon preadipocyte differentiation to adipocytes
Rattus norvegicus
-
3.1.3.4
neuron
PRG-1 is neuron-specific
Homo sapiens
-
3.1.3.4
neuron
PRG-1 is neuron-specific
Mus musculus
-
3.1.3.4
neuron
PRG-1 is neuron-specific
Rattus norvegicus
-
3.1.3.4
pancreas
isozyme LPP2
Homo sapiens
-
3.1.3.4
placenta
isozyme LPP2
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
ceramide 1-phosphate + H2O
-
666926
Mus musculus
ceramide + phosphate
-
-
-
?
3.1.3.4
ceramide 1-phosphate + H2O
-
666926
Homo sapiens
ceramide + phosphate
-
-
-
?
3.1.3.4
ceramide 1-phosphate + H2O
-
666926
Rattus norvegicus
ceramide + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
666926
Mus musculus
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
666926
Homo sapiens
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
666926
Rattus norvegicus
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes
666926
Mus musculus
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes
666926
Homo sapiens
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes
666926
Rattus norvegicus
?
-
-
-
-
3.1.3.4
additional information
Wunen and Wunen2 are involved in regulation of bioactive lipids and in survival and migration of germ cells, physiological roles of LPP isozymes
666926
Drosophila melanogaster
?
-
-
-
-
3.1.3.4
additional information
substrate specificities of isozymes
666926
Mus musculus
?
-
-
-
-
3.1.3.4
additional information
substrate specificities of isozymes
666926
Homo sapiens
?
-
-
-
-
3.1.3.4
additional information
substrate specificities of isozymes
666926
Rattus norvegicus
?
-
-
-
-
3.1.3.4
phosphatidic acid + H2O
-
666926
Mus musculus
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
phosphatidic acid + H2O
-
666926
Homo sapiens
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
phosphatidic acid + H2O
-
666926
Rattus norvegicus
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
666926
Mus musculus
sphingosine + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
666926
Homo sapiens
sphingosine + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
666926
Rattus norvegicus
sphingosine + phosphate
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
3.1.3.4
dimer
Wunen forms homodimers
Drosophila melanogaster
3.1.3.4
dimer
homodimer
Homo sapiens
3.1.3.4
dimer
homodimer
Mus musculus
3.1.3.4
dimer
homodimer
Rattus norvegicus
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.3.4
expression of LPP1 in Drosophila melanogaster cells S2
Mus musculus
3.1.3.4
overexpression of LPPs in HEK293 cells, expression of LPP3 in Drosophila melanogaster cells S2
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.3.4
additional information
no inhibition by NEM
Drosophila melanogaster
3.1.3.4
additional information
no inhibition by NEM
Homo sapiens
3.1.3.4
additional information
no inhibition by NEM
Mus musculus
3.1.3.4
additional information
no inhibition by NEM
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.4
caveola
isozymes LPP1 and LPP3
Homo sapiens
5901
-
3.1.3.4
caveola
isozymes LPP1 and LPP3
Mus musculus
5901
-
3.1.3.4
caveola
isozymes LPP1 and LPP3
Rattus norvegicus
5901
-
3.1.3.4
endoplasmic reticulum
isozyme LPP3
Homo sapiens
5783
-
3.1.3.4
endoplasmic reticulum
isozyme LPP3
Mus musculus
5783
-
3.1.3.4
endoplasmic reticulum
isozyme LPP3
Rattus norvegicus
5783
-
3.1.3.4
membrane
integral
Drosophila melanogaster
16020
-
3.1.3.4
membrane
integral
Homo sapiens
16020
-
3.1.3.4
membrane
integral
Mus musculus
16020
-
3.1.3.4
membrane
integral
Rattus norvegicus
16020
-
3.1.3.4
additional information
the enzyme also hydrolyses extracellularly located substrates
Drosophila melanogaster
-
-
3.1.3.4
additional information
the enzyme also hydrolyses extracellularly located substrates
Homo sapiens
-
-
3.1.3.4
additional information
the enzyme also hydrolyses extracellularly located substrates
Mus musculus
-
-
3.1.3.4
additional information
the enzyme also hydrolyses extracellularly located substrates
Rattus norvegicus
-
-
3.1.3.4
plasma membrane
-
Drosophila melanogaster
5886
-
3.1.3.4
plasma membrane
-
Homo sapiens
5886
-
3.1.3.4
plasma membrane
-
Mus musculus
5886
-
3.1.3.4
plasma membrane
-
Rattus norvegicus
5886
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.3.4
additional information
no requirement for Mg2+
Drosophila melanogaster
3.1.3.4
additional information
no requirement for Mg2+
Homo sapiens
3.1.3.4
additional information
no requirement for Mg2+
Mus musculus
3.1.3.4
additional information
no requirement for Mg2+
Rattus norvegicus
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
3.1.3.4
53000
83000
-
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
additional information
Mus musculus
LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes
?
-
-
-
3.1.3.4
additional information
Homo sapiens
LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes
?
-
-
-
3.1.3.4
additional information
Rattus norvegicus
LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes
?
-
-
-
3.1.3.4
additional information
Drosophila melanogaster
Wunen and Wunen2 are involved in regulation of bioactive lipids and in survival and migration of germ cells, physiological roles of LPP isozymes
?
-
-
-
Posttranslational Modification (protein specific)
EC Number
Posttranslational Modification
Commentary
Organism
3.1.3.4
glycoprotein
the glycosylation is not required for catalytic activity, no glycosylation of PRG-1
Homo sapiens
3.1.3.4
glycoprotein
the glycosylation is not required for catalytic activity, no glycosylation of PRG-1
Mus musculus
3.1.3.4
glycoprotein
the glycosylation is not required for catalytic activity, no glycosylation of PRG-1
Rattus norvegicus
3.1.3.4
phosphoprotein
reversible phosphorylation might play a role in enzyme regulation
Homo sapiens
3.1.3.4
phosphoprotein
reversible phosphorylation might play a role in enzyme regulation
Mus musculus
3.1.3.4
phosphoprotein
reversible phosphorylation might play a role in enzyme regulation
Rattus norvegicus
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.3.4
from liver
Rattus norvegicus
3.1.3.4
recombinant LPP1 from Drosophila melanogaster cells S2 by immunoaffinity
Mus musculus
3.1.3.4
recombinant LPP3 from Drosophila melanogaster cells S2 by immunoaffinity
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
adipocyte
-
Rattus norvegicus
-
3.1.3.4
brain
isozyme LPP2
Homo sapiens
-
3.1.3.4
embryo
expression pattern of Wun and Wun2 during embryogenesis
Drosophila melanogaster
-
3.1.3.4
epithelium
-
Rattus norvegicus
-
3.1.3.4
germ cell
-
Drosophila melanogaster
-
3.1.3.4
gonad
-
Drosophila melanogaster
-
3.1.3.4
hindgut
primordium
Drosophila melanogaster
-
3.1.3.4
intestinal epithelium
isozyme LPP3
Homo sapiens
-
3.1.3.4
intestinal epithelium
isozyme LPP3
Mus musculus
-
3.1.3.4
intestinal epithelium
isozyme LPP3
Rattus norvegicus
-
3.1.3.4
kidney
isozyme LPP2
Mus musculus
-
3.1.3.4
liver
isozyme LPP2
Mus musculus
-
3.1.3.4
liver
-
Rattus norvegicus
-
3.1.3.4
lung
isozyme LPP2
Mus musculus
-
3.1.3.4
mesoderm
-
Drosophila melanogaster
-
3.1.3.4
midgut
-
Drosophila melanogaster
-
3.1.3.4
additional information
expression pattern and translocation of Wun and Wun2 during gut development
Drosophila melanogaster
-
3.1.3.4
additional information
isozymes LPP1 and LPP3 show a wide tissue distribution
Homo sapiens
-
3.1.3.4
additional information
isozymes LPP1 and LPP3 show a wide tissue distribution
Mus musculus
-
3.1.3.4
additional information
the expression of LPP1-3 is reduced upon preadipocyte differentiation to adipocytes
Rattus norvegicus
-
3.1.3.4
neuron
PRG-1 is neuron-specific
Homo sapiens
-
3.1.3.4
neuron
PRG-1 is neuron-specific
Mus musculus
-
3.1.3.4
neuron
PRG-1 is neuron-specific
Rattus norvegicus
-
3.1.3.4
pancreas
isozyme LPP2
Homo sapiens
-
3.1.3.4
placenta
isozyme LPP2
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
ceramide 1-phosphate + H2O
-
666926
Mus musculus
ceramide + phosphate
-
-
-
?
3.1.3.4
ceramide 1-phosphate + H2O
-
666926
Homo sapiens
ceramide + phosphate
-
-
-
?
3.1.3.4
ceramide 1-phosphate + H2O
-
666926
Rattus norvegicus
ceramide + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
666926
Mus musculus
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
666926
Homo sapiens
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
666926
Rattus norvegicus
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes
666926
Mus musculus
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes
666926
Homo sapiens
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes
666926
Rattus norvegicus
?
-
-
-
-
3.1.3.4
additional information
Wunen and Wunen2 are involved in regulation of bioactive lipids and in survival and migration of germ cells, physiological roles of LPP isozymes
666926
Drosophila melanogaster
?
-
-
-
-
3.1.3.4
additional information
substrate specificities of isozymes
666926
Mus musculus
?
-
-
-
-
3.1.3.4
additional information
substrate specificities of isozymes
666926
Homo sapiens
?
-
-
-
-
3.1.3.4
additional information
substrate specificities of isozymes
666926
Rattus norvegicus
?
-
-
-
-
3.1.3.4
phosphatidic acid + H2O
-
666926
Mus musculus
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
phosphatidic acid + H2O
-
666926
Homo sapiens
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
phosphatidic acid + H2O
-
666926
Rattus norvegicus
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
666926
Mus musculus
sphingosine + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
666926
Homo sapiens
sphingosine + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
666926
Rattus norvegicus
sphingosine + phosphate
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
3.1.3.4
dimer
Wunen forms homodimers
Drosophila melanogaster
3.1.3.4
dimer
homodimer
Homo sapiens
3.1.3.4
dimer
homodimer
Mus musculus
3.1.3.4
dimer
homodimer
Rattus norvegicus