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Literature summary extracted from
- Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases (2004), Semin. Cell Dev. Biol., 15, 491-501.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.3.4 | expression of LPP1 in Drosophila melanogaster cells S2 | Mus musculus |
| 3.1.3.4 | overexpression of LPPs in HEK293 cells, expression of LPP3 in Drosophila melanogaster cells S2 | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.4 | additional information | no inhibition by NEM | Drosophila melanogaster | |
| 3.1.3.4 | additional information | no inhibition by NEM | Homo sapiens | |
| 3.1.3.4 | additional information | no inhibition by NEM | Mus musculus | |
| 3.1.3.4 | additional information | no inhibition by NEM | Rattus norvegicus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.3.4 | caveola | isozymes LPP1 and LPP3 | Mus musculus | 5901 | - |
| 3.1.3.4 | caveola | isozymes LPP1 and LPP3 | Homo sapiens | 5901 | - |
| 3.1.3.4 | caveola | isozymes LPP1 and LPP3 | Rattus norvegicus | 5901 | - |
| 3.1.3.4 | endoplasmic reticulum | isozyme LPP3 | Mus musculus | 5783 | - |
| 3.1.3.4 | endoplasmic reticulum | isozyme LPP3 | Homo sapiens | 5783 | - |
| 3.1.3.4 | endoplasmic reticulum | isozyme LPP3 | Rattus norvegicus | 5783 | - |
| 3.1.3.4 | membrane | integral | Drosophila melanogaster | 16020 | - |
| 3.1.3.4 | membrane | integral | Mus musculus | 16020 | - |
| 3.1.3.4 | membrane | integral | Homo sapiens | 16020 | - |
| 3.1.3.4 | membrane | integral | Rattus norvegicus | 16020 | - |
| 3.1.3.4 | additional information | the enzyme also hydrolyses extracellularly located substrates | Drosophila melanogaster | - |
- |
| 3.1.3.4 | additional information | the enzyme also hydrolyses extracellularly located substrates | Mus musculus | - |
- |
| 3.1.3.4 | additional information | the enzyme also hydrolyses extracellularly located substrates | Homo sapiens | - |
- |
| 3.1.3.4 | additional information | the enzyme also hydrolyses extracellularly located substrates | Rattus norvegicus | - |
- |
| 3.1.3.4 | plasma membrane | - |
Drosophila melanogaster | 5886 | - |
| 3.1.3.4 | plasma membrane | - |
Mus musculus | 5886 | - |
| 3.1.3.4 | plasma membrane | - |
Homo sapiens | 5886 | - |
| 3.1.3.4 | plasma membrane | - |
Rattus norvegicus | 5886 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.4 | additional information | no requirement for Mg2+ | Drosophila melanogaster | |
| 3.1.3.4 | additional information | no requirement for Mg2+ | Mus musculus | |
| 3.1.3.4 | additional information | no requirement for Mg2+ | Homo sapiens | |
| 3.1.3.4 | additional information | no requirement for Mg2+ | Rattus norvegicus |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.3.4 | 53000 | 83000 | - |
Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.4 | additional information | Mus musculus | LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes | ? | - |
? |  |
| 3.1.3.4 | additional information | Homo sapiens | LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes | ? | - |
? | |
| 3.1.3.4 | additional information | Rattus norvegicus | LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes | ? | - |
? | |
| 3.1.3.4 | additional information | Drosophila melanogaster | Wunen and Wunen2 are involved in regulation of bioactive lipids and in survival and migration of germ cells, physiological roles of LPP isozymes | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.3.4 | Drosophila melanogaster | - |
- |
- |
| 3.1.3.4 | Homo sapiens | - |
isozymes LPP1-3, several splicing variants of LPP1 | - |
| 3.1.3.4 | Mus musculus | - |
isozymes LPP1-3, several splicing variants of LPP1 | - |
| 3.1.3.4 | Rattus norvegicus | - |
isozymes LPP1-3, several splicing variants of LPP1 | - |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.1.3.4 | glycoprotein | the glycosylation is not required for catalytic activity, no glycosylation of PRG-1 | Mus musculus |
| 3.1.3.4 | glycoprotein | the glycosylation is not required for catalytic activity, no glycosylation of PRG-1 | Homo sapiens |
| 3.1.3.4 | glycoprotein | the glycosylation is not required for catalytic activity, no glycosylation of PRG-1 | Rattus norvegicus |
| 3.1.3.4 | phosphoprotein | reversible phosphorylation might play a role in enzyme regulation | Mus musculus |
| 3.1.3.4 | phosphoprotein | reversible phosphorylation might play a role in enzyme regulation | Homo sapiens |
| 3.1.3.4 | phosphoprotein | reversible phosphorylation might play a role in enzyme regulation | Rattus norvegicus |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.3.4 | from liver | Rattus norvegicus |
| 3.1.3.4 | recombinant LPP1 from Drosophila melanogaster cells S2 by immunoaffinity | Mus musculus |
| 3.1.3.4 | recombinant LPP3 from Drosophila melanogaster cells S2 by immunoaffinity | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.3.4 | adipocyte | - |
Rattus norvegicus | - |
| 3.1.3.4 | brain | isozyme LPP2 | Homo sapiens | - |
| 3.1.3.4 | embryo | expression pattern of Wun and Wun2 during embryogenesis | Drosophila melanogaster | - |
| 3.1.3.4 | epithelium | - |
Rattus norvegicus | - |
| 3.1.3.4 | germ cell | - |
Drosophila melanogaster | - |
| 3.1.3.4 | gonad | - |
Drosophila melanogaster | - |
| 3.1.3.4 | hindgut | primordium | Drosophila melanogaster | - |
| 3.1.3.4 | intestinal epithelium | isozyme LPP3 | Mus musculus | - |
| 3.1.3.4 | intestinal epithelium | isozyme LPP3 | Homo sapiens | - |
| 3.1.3.4 | intestinal epithelium | isozyme LPP3 | Rattus norvegicus | - |
| 3.1.3.4 | kidney | isozyme LPP2 | Mus musculus | - |
| 3.1.3.4 | liver | - |
Rattus norvegicus | - |
| 3.1.3.4 | liver | isozyme LPP2 | Mus musculus | - |
| 3.1.3.4 | lung | isozyme LPP2 | Mus musculus | - |
| 3.1.3.4 | mesoderm | - |
Drosophila melanogaster | - |
| 3.1.3.4 | midgut | - |
Drosophila melanogaster | - |
| 3.1.3.4 | additional information | expression pattern and translocation of Wun and Wun2 during gut development | Drosophila melanogaster | - |
| 3.1.3.4 | additional information | isozymes LPP1 and LPP3 show a wide tissue distribution | Mus musculus | - |
| 3.1.3.4 | additional information | isozymes LPP1 and LPP3 show a wide tissue distribution | Homo sapiens | - |
| 3.1.3.4 | additional information | the expression of LPP1-3 is reduced upon preadipocyte differentiation to adipocytes | Rattus norvegicus | - |
| 3.1.3.4 | neuron | PRG-1 is neuron-specific | Mus musculus | - |
| 3.1.3.4 | neuron | PRG-1 is neuron-specific | Homo sapiens | - |
| 3.1.3.4 | neuron | PRG-1 is neuron-specific | Rattus norvegicus | - |
| 3.1.3.4 | pancreas | isozyme LPP2 | Homo sapiens | - |
| 3.1.3.4 | placenta | isozyme LPP2 | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.4 | ceramide 1-phosphate + H2O | - |
Mus musculus | ceramide + phosphate | - |
? | |
| 3.1.3.4 | ceramide 1-phosphate + H2O | - |
Homo sapiens | ceramide + phosphate | - |
? | |
| 3.1.3.4 | ceramide 1-phosphate + H2O | - |
Rattus norvegicus | ceramide + phosphate | - |
? | |
| 3.1.3.4 | lysophosphatidic acid + H2O | - |
Mus musculus | monoacylglycerol + phosphate | - |
? | |
| 3.1.3.4 | lysophosphatidic acid + H2O | - |
Homo sapiens | monoacylglycerol + phosphate | - |
? | |
| 3.1.3.4 | lysophosphatidic acid + H2O | - |
Rattus norvegicus | monoacylglycerol + phosphate | - |
? | |
| 3.1.3.4 | additional information | LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes | Mus musculus | ? | - |
? | |
| 3.1.3.4 | additional information | LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes | Homo sapiens | ? | - |
? | |
| 3.1.3.4 | additional information | LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes | Rattus norvegicus | ? | - |
? | |
| 3.1.3.4 | additional information | Wunen and Wunen2 are involved in regulation of bioactive lipids and in survival and migration of germ cells, physiological roles of LPP isozymes | Drosophila melanogaster | ? | - |
? | |
| 3.1.3.4 | additional information | substrate specificities of isozymes | Mus musculus | ? | - |
? | |
| 3.1.3.4 | additional information | substrate specificities of isozymes | Homo sapiens | ? | - |
? | |
| 3.1.3.4 | additional information | substrate specificities of isozymes | Rattus norvegicus | ? | - |
? | |
| 3.1.3.4 | phosphatidic acid + H2O | - |
Mus musculus | diacylglycerol + phosphate | - |
? | |
| 3.1.3.4 | phosphatidic acid + H2O | - |
Homo sapiens | diacylglycerol + phosphate | - |
? | |
| 3.1.3.4 | phosphatidic acid + H2O | - |
Rattus norvegicus | diacylglycerol + phosphate | - |
? | |
| 3.1.3.4 | sphingosine 1-phosphate + H2O | - |
Mus musculus | sphingosine + phosphate | - |
? | |
| 3.1.3.4 | sphingosine 1-phosphate + H2O | - |
Homo sapiens | sphingosine + phosphate | - |
? | |
| 3.1.3.4 | sphingosine 1-phosphate + H2O | - |
Rattus norvegicus | sphingosine + phosphate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.3.4 | dimer | homodimer | Mus musculus |
| 3.1.3.4 | dimer | homodimer | Homo sapiens |
| 3.1.3.4 | dimer | homodimer | Rattus norvegicus |
| 3.1.3.4 | dimer | Wunen forms homodimers | Drosophila melanogaster |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.3.4 | Dri42 | i.e. isozyme LPP3 | Rattus norvegicus |
| 3.1.3.4 | lipid phosphate phosphatase | - |
Drosophila melanogaster |
| 3.1.3.4 | lipid phosphate phosphatase | - |
Mus musculus |
| 3.1.3.4 | lipid phosphate phosphatase | - |
Homo sapiens |
| 3.1.3.4 | lipid phosphate phosphatase | - |
Rattus norvegicus |
| 3.1.3.4 | LPP | - |
Drosophila melanogaster |
| 3.1.3.4 | LPP | - |
Mus musculus |
| 3.1.3.4 | LPP | - |
Homo sapiens |
| 3.1.3.4 | LPP | - |
Rattus norvegicus |
| 3.1.3.4 | More | the enzyme belongs to the lipid phosphate phosphatase family | Drosophila melanogaster |
| 3.1.3.4 | More | the enzyme belongs to the lipid phosphate phosphatase family | Mus musculus |
| 3.1.3.4 | More | the enzyme belongs to the lipid phosphate phosphatase family | Homo sapiens |
| 3.1.3.4 | More | the enzyme belongs to the lipid phosphate phosphatase family | Rattus norvegicus |
| 3.1.3.4 | PRG-1 | plasticity-related gene-1 | Mus musculus |
| 3.1.3.4 | PRG-1 | plasticity-related gene-1 | Homo sapiens |
| 3.1.3.4 | PRG-1 | plasticity-related gene-1 | Rattus norvegicus |
| 3.1.3.4 | Wunen | - |
Drosophila melanogaster |
| 3.1.3.4 | Wunen2 | - |
Drosophila melanogaster |
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