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Literature summary extracted from
- Leukotriene C4 synthase (2003), Prostaglandins Leukot. Essent. Fatty Acids, 69, 111-116.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.20 | Mg2+ | - |
Homo sapiens |  |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.4.1.20 | - |
Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 4.4.1.20 | C56S | not inhibited by N-ethylmaleimide | Homo sapiens |
| 4.4.1.20 | R51I | inactive | Homo sapiens |
| 4.4.1.20 | Y93F | reduces the enzyme activity to less than 1% of the wild-type enzyme, shift in the pH-optimum | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.20 | Co2+ | - |
Homo sapiens | |
| 4.4.1.20 | MK-886 | - |
Homo sapiens | |
| 4.4.1.20 | N-ethylmaleimide | inhibits the recombinant enzyme | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.4.1.20 | 0.0036 | - |
leukotriene A4 | human recombinant enzyme | Homo sapiens | |
| 4.4.1.20 | 1.6 | - |
glutathione | human recombinant enzyme | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.4.1.20 | membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.20 | Co2+ | inhibits the enzyme | Homo sapiens | |
| 4.4.1.20 | Mg2+ | augments the enzyme | Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.4.1.20 | 18000 | - |
2 * 18000, SDS-PAGE, gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.4.1.20 | leukotriene C4 | Homo sapiens | - |
leukotriene A4 + glutathione | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.4.1.20 | Homo sapiens | Q16873 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.4.1.20 | to homogeneity | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.4.1.20 | KG-1 cell | - |
Homo sapiens | - |
| 4.4.1.20 | lung | - |
Homo sapiens | - |
| 4.4.1.20 | THP-1 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.4.1.20 | leukotriene A4 + glutathione | - |
Homo sapiens | leukotriene C4 | - |
r | |
| 4.4.1.20 | leukotriene C4 | - |
Homo sapiens | leukotriene A4 + glutathione | - |
r | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.4.1.20 | dimer | 2 * 18000, SDS-PAGE, gel filtration | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.4.1.20 | leukotriene C4 synthase | - |
Homo sapiens |
| 4.4.1.20 | LTC4 synthase | - |
Homo sapiens |
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