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Literature summary extracted from

  • Lee, S.J.; Xu, H.; Montell, C.
    Rhodopsin kinase activity modulates the amplitude of the visual response in Drosophila (2004), Proc. Natl. Acad. Sci. USA, 101, 11874-11879.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.14 G-protein dependent on Drosophila melanogaster

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.14 overexpression of myc-tagged wild-type and K220R mutant enzyme fused to heat shock inducible promotors in photoreceptor cells of flies, cells overexpressing the wild-type enzyme show increased phosphorhodopsin content after heat shock activation Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.14 K220R site-directed mutagenesis, ATP binding site mutation, inactive mutant Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.14 membrane
-
 Drosophila melanogaster 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.14 Mg2+
-
 Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.14 ATP + rhodopsin 1 Drosophila melanogaster
-
 ADP + phosphorhodopsin 1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.14 Drosophila melanogaster
-
 gene gprk1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.14 eye adult Drosophila melanogaster
-
2.7.11.14 head
-
 Drosophila melanogaster
-
2.7.11.14 photoreceptor most GPRK1 in the eye Drosophila melanogaster
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.14 additional information
-
 assay at dark Drosophila melanogaster

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.14 ATP + rhodopsin 1
-
 Drosophila melanogaster ADP + phosphorhodopsin 1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.14 G-protein coupled receptor kinase
-
 Drosophila melanogaster
2.7.11.14 GPRK1
-
 Drosophila melanogaster
2.7.11.14 GRK1
-
 Drosophila melanogaster
2.7.11.14 GRK7
-
 Drosophila melanogaster
2.7.11.14 RK
-
 Drosophila melanogaster

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.14 25
-
 assay at Drosophila melanogaster

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.14 7.5
-
 assay at Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.14 ATP
-
 Drosophila melanogaster